CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK¹ lymphoma after transplantation

TY - JOUR

T1 - CRISPR genome editing of murine hematopoietic stem cells to create Npm1-Alk causes ALK1 lymphoma after transplantation

AU - Rajan, Soumya Sundara

AU - Li, Lingxiao

AU - Kweh, Mercedes F.

AU - Kunkalla, Kranthi

AU - Amin, Amit Dipak

AU - Agarwal, Nitin K.

AU - Vega, Francisco

AU - Schatz, Jonathan H.

N1 - Funding Information: This work was supported by National Institutes of Health, National Cancer Institute grant 1R01CA190696-01 (J.H.S.). Funding Information: The authors thank the Sheila and David Fuente Graduate Program in Cancer Biology at the University of Miami and are extremely grateful to Andrea Ventura (Memorial Sloan Kettering Cancer Center, New York, NY) and Danilo Maddalo (Novartis) for providing the sgNpm-Alk plasmid. The authors thank Mingjiang Xu (University of Miami) for developing the pathology core and helping with the slides for H&E staining and IHC, and as well as the laboratory of Feng-Chun Yang (University of Miami) for extensive use of the microscope camera. This work was supported by National Institutes of Health, National Cancer Institute grant 1R01CA190696-01 (J.H.S.).

PY - 2019

Y1 - 2019

UR - https://www.scopus.com/pages/publications/85068918760

UR - https://www.scopus.com/pages/publications/85068918760#tab=citedBy

U2 - 10.1182/bloodadvances.2018025247

DO - 10.1182/bloodadvances.2018025247

M3 - Review article

C2 - 31189527

AN - SCOPUS:85068918760

SN - 2473-9529

VL - 3

SP - 1788

EP - 1794

JO - Blood Advances

JF - Blood Advances

IS - 12

ER -