@article{be8c22ff0910467db645a47f62eb19dd,
title = "Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy",
abstract = "The regulation of cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.",
keywords = "Rb-E2F pathway, cell cycle entry, cellular quiescence, quiescence depth",
author = "Kotaro Fujimaki and Guang Yao",
note = "Funding Information: We apologize to colleagues whose work could not be cited due to space limitations. This work was supported by grants from the NSF (DMS-1463137 and DMS-1418172) and DARPA (WF911NF-14-1-0395). Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2018, {\textcopyright} Kotaro Fujimaki and Guang Yao.",
year = "2018",
month = jan,
day = "2",
doi = "10.1080/23723556.2017.1403531",
language = "English (US)",
volume = "5",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "1",
}