CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion

David A. Spiegel; Jón T. Njardarson; John L. Wood

doi:10.1016/S0040-4020(02)00664-6

CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion

David A. Spiegel
, Jón T. Njardarson
, John L. Wood

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Described is a rhodium carbenoid C-H insertion strategy for the construction of an isotwistane ring system needed for a late-stage fragmentation en route to the total synthesis of CP-263,114.

Original language	English (US)
Pages (from-to)	6545-6554
Number of pages	10
Journal	Tetrahedron
Volume	58
Issue number	32
DOIs	https://doi.org/10.1016/S0040-4020(02)00664-6
State	Published - Aug 5 2002
Externally published	Yes

Keywords

C-H insertion
CP-263,114
Diazo
Isotwistane
Phomoidrides
Rhodium carbenoid
β-ketoester

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(02)00664-6

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title = "CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion",

abstract = "Described is a rhodium carbenoid C-H insertion strategy for the construction of an isotwistane ring system needed for a late-stage fragmentation en route to the total synthesis of CP-263,114.",

keywords = "C-H insertion, CP-263,114, Diazo, Isotwistane, Phomoidrides, Rhodium carbenoid, β-ketoester",

author = "Spiegel, \{David A.\} and Njardarson, \{J{\'o}n T.\} and Wood, \{John L.\}",

note = "Funding Information: We acknowledge the support of this work by Bristol-Myers Squibb, Eli Lilly, Glaxo-Wellcome, Yamanouchi and Zeneca through their Faculty Awards Programs and the Camille and Henry Dreyfus Foundation for a Teacher–Scholar Award. We thank Susan de Gala for securing the X-ray crystallographic analyses. ",

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doi = "10.1016/S0040-4020(02)00664-6",

language = "English (US)",

volume = "58",

pages = "6545--6554",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "32",

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T1 - CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion

AU - Spiegel, David A.

AU - Njardarson, Jón T.

AU - Wood, John L.

N1 - Funding Information: We acknowledge the support of this work by Bristol-Myers Squibb, Eli Lilly, Glaxo-Wellcome, Yamanouchi and Zeneca through their Faculty Awards Programs and the Camille and Henry Dreyfus Foundation for a Teacher–Scholar Award. We thank Susan de Gala for securing the X-ray crystallographic analyses.

PY - 2002/8/5

Y1 - 2002/8/5

N2 - Described is a rhodium carbenoid C-H insertion strategy for the construction of an isotwistane ring system needed for a late-stage fragmentation en route to the total synthesis of CP-263,114.

AB - Described is a rhodium carbenoid C-H insertion strategy for the construction of an isotwistane ring system needed for a late-stage fragmentation en route to the total synthesis of CP-263,114.

KW - C-H insertion

KW - CP-263,114

KW - Diazo

KW - Isotwistane

KW - Phomoidrides

KW - Rhodium carbenoid

KW - β-ketoester

UR - https://www.scopus.com/pages/publications/0037025928

UR - https://www.scopus.com/pages/publications/0037025928#tab=citedBy

U2 - 10.1016/S0040-4020(02)00664-6

DO - 10.1016/S0040-4020(02)00664-6

M3 - Article

AN - SCOPUS:0037025928

SN - 0040-4020

VL - 58

SP - 6545

EP - 6554

JO - Tetrahedron

JF - Tetrahedron

IS - 32

ER -

CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion

Abstract

Keywords

ASJC Scopus subject areas

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