TY - JOUR
T1 - Covalent surface chemical modification of electrodes for cardiac pacing applications
AU - Schoenfisch, Mark H.
AU - Ovadia, Marc
AU - Pemberton, Jeanne E.
PY - 2000
Y1 - 2000
N2 - We report the covalent surface modification of active-fixation pacemaker electrodes with butanethiol or dodecanethiol self-assembled monolayers (SAMs) using a platinum or gold metal-thiolate bond (i.e., changing the chemical identity of the exposed metal electrode from metal to organic) in such fashion that (a) the surface is organic in functionality with lipophilic physicochemical characteristics, (b) a possible degradation product is gold (I)-alkanethiolate with putative anti-inflammatory actions, and (c) current density/electric field strength is increased. Superior acute and chronic pacing performance with dodecanethiol-modified, gold-coated, platinum-iridium alloy pacemaker electrodes was observed with inferential evidence of reduced inflammation and scar. This approach may have applicability in other areas of bioelectrodes with practical applications in clinical cardiology, surgery, neuroscience, and subcutaneous sensors. (C) 2000 John wiley and Sons, Inc.
AB - We report the covalent surface modification of active-fixation pacemaker electrodes with butanethiol or dodecanethiol self-assembled monolayers (SAMs) using a platinum or gold metal-thiolate bond (i.e., changing the chemical identity of the exposed metal electrode from metal to organic) in such fashion that (a) the surface is organic in functionality with lipophilic physicochemical characteristics, (b) a possible degradation product is gold (I)-alkanethiolate with putative anti-inflammatory actions, and (c) current density/electric field strength is increased. Superior acute and chronic pacing performance with dodecanethiol-modified, gold-coated, platinum-iridium alloy pacemaker electrodes was observed with inferential evidence of reduced inflammation and scar. This approach may have applicability in other areas of bioelectrodes with practical applications in clinical cardiology, surgery, neuroscience, and subcutaneous sensors. (C) 2000 John wiley and Sons, Inc.
KW - Alkanethiol self-assembled monolayers
KW - Biocompatibility
KW - Covalent surface modification
KW - Pacemaker
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U2 - 10.1002/(SICI)1097-4636(200008)51:2<209::AID-JBM9>3.0.CO;2-5
DO - 10.1002/(SICI)1097-4636(200008)51:2<209::AID-JBM9>3.0.CO;2-5
M3 - Article
C2 - 10825220
AN - SCOPUS:0034129944
SN - 0021-9304
VL - 51
SP - 209
EP - 215
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
IS - 2
ER -