Cosolvent-Induced Solubilization of Hydrophobic Compounds into Water

Sujit Banerjee; Samuel H. Yalkowsky

doi:10.1021/ac00170a034

Cosolvent-Induced Solubilization of Hydrophobic Compounds into Water

Sujit Banerjee, Samuel H. Yalkowsky

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The solubilization of toluene Into water by propylene glycol and methanol was measured by a novel liquid chromatographic procedure. The relationship between solubilization and cosolvent content Is linear up to 10-20 vol % of cosolvent, beyond which conventional logarithmic behavior Is observed. The point of departure from linearity Is believed to signal the onset of Interaction between the extended hydration shells of the cosolvent. For propylene glycol, the volume of this shell Is about 500 mL/mol, and the solubility of toluene within the shell Is about 1.3 times Its solubility In pure water.

Original language	English (US)
Pages (from-to)	2153-2155
Number of pages	3
Journal	Analytical Chemistry
Volume	60
Issue number	19
DOIs	https://doi.org/10.1021/ac00170a034
State	Published - Oct 1 1988

ASJC Scopus subject areas

Analytical Chemistry

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abstract = "The solubilization of toluene Into water by propylene glycol and methanol was measured by a novel liquid chromatographic procedure. The relationship between solubilization and cosolvent content Is linear up to 10-20 vol % of cosolvent, beyond which conventional logarithmic behavior Is observed. The point of departure from linearity Is believed to signal the onset of Interaction between the extended hydration shells of the cosolvent. For propylene glycol, the volume of this shell Is about 500 mL/mol, and the solubility of toluene within the shell Is about 1.3 times Its solubility In pure water.",

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year = "1988",

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AU - Banerjee, Sujit

AU - Yalkowsky, Samuel H.

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N2 - The solubilization of toluene Into water by propylene glycol and methanol was measured by a novel liquid chromatographic procedure. The relationship between solubilization and cosolvent content Is linear up to 10-20 vol % of cosolvent, beyond which conventional logarithmic behavior Is observed. The point of departure from linearity Is believed to signal the onset of Interaction between the extended hydration shells of the cosolvent. For propylene glycol, the volume of this shell Is about 500 mL/mol, and the solubility of toluene within the shell Is about 1.3 times Its solubility In pure water.

AB - The solubilization of toluene Into water by propylene glycol and methanol was measured by a novel liquid chromatographic procedure. The relationship between solubilization and cosolvent content Is linear up to 10-20 vol % of cosolvent, beyond which conventional logarithmic behavior Is observed. The point of departure from linearity Is believed to signal the onset of Interaction between the extended hydration shells of the cosolvent. For propylene glycol, the volume of this shell Is about 500 mL/mol, and the solubility of toluene within the shell Is about 1.3 times Its solubility In pure water.

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JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 19

ER -

Cosolvent-Induced Solubilization of Hydrophobic Compounds into Water

Abstract

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