Cortical blood flow and negative symptoms in schizophrenia

Zvi Zemishlany, Gene E. Alexander, Isak Prohovnik, Ron G. Goldman, Sukdeb Mukherjee, Harold Sackeim

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


An association between negative symptoms and frontal cortex abnormalities has been suggested in schizophrenic patients. We tested whether this assocation can be found when patients’ task performance is good and while controlling for possible cortical atrophy. We investigated regional cerebral blood flow with the xenon-133 inhalation method in 9 unmedicated schizophrenic patients at rest and during performance of the Continuous Performance Test. Negative symptoms were quantified with the Scale for Assessment of Negative Symptoms. All patients could attend to the test and performed it successfully with mean accuracy of 91 ± 8%. Changes of the left hemisphere hyperfrontality ratio were significantly correlated with severity of negative symptoms, especially for the subscales of attention (r = −0.83) and anhedonia (r = −0.70). These results lend further support to the putative association between negative symptoms and physiological abnormalities of the frontal cortex in schizophrenic patients.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
Issue number3
StatePublished - 1996


  • Cerebral activation
  • Cerebral blood flow
  • Cerebral metabolism
  • Continuous Performance Test
  • Hypofrontality
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry


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