Abstract
The effects of systematic alteration of vehicle composition on the release rate of drugs from their vehicle were studied. Equations were developed which quantitatively predict the rate of transport of a drug across a membrane separating two identical binary aqueous solvents. Separate equations were derived for solutions and for suspensions, which account for both the resistance of the membrane and the resistance of the solvent to drug diffusion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1276-1280 |
| Number of pages | 5 |
| Journal | Journal of pharmaceutical sciences |
| Volume | 63 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1974 |
Keywords
- Drug release rates‐effects of systematic alteration of vehicle composition, solutions and suspensions, equations
- Membrane diffusion‐effect of vehicle polarity on flux from solutions and suspensions, systematic alteration of vehicle composition, equations
- Vehicle polarity‐effect of systematic alteration of vehicle composition on release rates of drugs, equations
ASJC Scopus subject areas
- Pharmaceutical Science