TY - JOUR
T1 - Correlates of 25-hydroxyvitamin D and breast cancer stage in the women's healthy eating and living study
AU - Jacobs, Elizabeth T.
AU - Thomson, Cynthia A.
AU - Flatt, Shirley W.
AU - Newman, Vicky A.
AU - Rock, Cheryl L.
AU - Pierce, John P.
N1 - Funding Information:
This work was supported by the National Cancer Institute at the National Institutes of Health [K07CA106269 (Elizabeth T. Jacobs) and R01CA134460 (Elizabeth T. Jacobs)]. Support for the WHEL Study was provided by the National Cancer Institute at the National Institutes of Health Grant CA69375, with General Clinical Research Centers NIH grants M01-RR00070, M01-RR00079, and M01-RR00827.
PY - 2013
Y1 - 2013
N2 - Inverse associations between circulating 25-hydroxyvitamin D [25(OH)D] and breast cancer stage have been reported, thus it is critical to understand the variables that contribute to 25(OH)D levels among women with breast cancer. Among 904 women in the Women's Healthy Eating and Living Study, plasma 25(OH)D concentrations were measured and data on demographic characteristics, diet, physical activity, and tumor characteristics were collected at study entry. Statistically significant associations with 25(OH)D concentrations were observed for body mass index (BMI), body surface area (BSA), height, smoking, total vitamin D intake, physical activity, and race or ethnicity. Of the correlates of 25(OH)D, BMI, BSA, height, physical activity, and study site were associated with stage of breast cancer; however, concentrations of 25(OH)D were not significantly related to stage. In fully adjusted logistic regression models, the ORs (95% CIs) for the association between vitamin D deficiency and Stage II and III cancers were 0.85 (0.59-1.22) and 1.23 (0.71-2.15), respectively (P trend = 0.59), compared to Stage I. This study confirms previous work regarding the correlates of 25(OH)D concentrations but does not provide support for an association between vitamin D status and breast cancer stage.
AB - Inverse associations between circulating 25-hydroxyvitamin D [25(OH)D] and breast cancer stage have been reported, thus it is critical to understand the variables that contribute to 25(OH)D levels among women with breast cancer. Among 904 women in the Women's Healthy Eating and Living Study, plasma 25(OH)D concentrations were measured and data on demographic characteristics, diet, physical activity, and tumor characteristics were collected at study entry. Statistically significant associations with 25(OH)D concentrations were observed for body mass index (BMI), body surface area (BSA), height, smoking, total vitamin D intake, physical activity, and race or ethnicity. Of the correlates of 25(OH)D, BMI, BSA, height, physical activity, and study site were associated with stage of breast cancer; however, concentrations of 25(OH)D were not significantly related to stage. In fully adjusted logistic regression models, the ORs (95% CIs) for the association between vitamin D deficiency and Stage II and III cancers were 0.85 (0.59-1.22) and 1.23 (0.71-2.15), respectively (P trend = 0.59), compared to Stage I. This study confirms previous work regarding the correlates of 25(OH)D concentrations but does not provide support for an association between vitamin D status and breast cancer stage.
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U2 - 10.1080/01635581.2013.756531
DO - 10.1080/01635581.2013.756531
M3 - Article
C2 - 23441606
AN - SCOPUS:84874614883
SN - 0163-5581
VL - 65
SP - 188
EP - 194
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 2
ER -