Coronary sinus and fossa ovalis ablation: Effect on interatrial conduction and atrial fibrillation

Peter Ott, Malcolm M. Kirk, Charles Koo, Ding Sheng He, Baishali Bhattacharya, Alfred Buxton

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Coronary Sinus and Fossa Ovalis Ablation. Background: Interatrial conduction occurs via discrete pathways along the coronary sinus musculature, fossa ovalis region, and Bachman's bundle. We assessed the feasibility of altering interatrial conduction by selectively ablating two of these conduction pathways using a novel mesh electrode ablation catheter. Methods: Circular radiofrequency energy catheter ablation lesions were created in the proximal coronary sinus in four dogs and in both the fossa ovalis and the proximal coronary sinus regions in seven pigs. Interatrial conduction was assessed by analyzing intracardiac electrogram and noncontact isopotential mapping data. Inducibility of atrial fibrillation was assessed before and after ablation (in six pigs). Results: Ablation lesions in the proximal coronary sinus eliminated interatrial conduction along the coronary sinus musculature in four dogs and five of seven pigs. Ablation lesions in the fossa ovalis region eliminated interatrial conduction via midseptal pathways in six of seven pigs. Atrial fibrillation, inducible in five of seven pigs at baseline, was rendered noninducible in all five. There was no adverse effect on AV nodal conduction. Conclusions: (1) Using a novel mesh electrode ablation catheter, we were able to ablate interatrial conduction pathways along the proximal coronary sinus and fossa ovalis regions. (2) This altered interatrial conduction and altered atrial fibrillation inducibility and maintenance. (3) Catheter ablation of interatrial conduction pathways may be useful in the therapy of atrial fibrillation.

Original languageEnglish (US)
Pages (from-to)310-317
Number of pages8
JournalJournal of cardiovascular electrophysiology
Issue number3
StatePublished - Mar 2007


  • Atrial fibrillation
  • Catheter ablation
  • Interatrial conduction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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