Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin

Guojun Wang, Pallab Pahari, Madan K. Kharel, Jing Chen, Haining Zhu, Steven G. Vanlanen, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

24 Scopus citations
Original languageEnglish (US)
Pages (from-to)10638-10642
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number42
DOIs
StatePublished - Oct 15 2012
Externally publishedYes

Keywords

  • 4-ketoreductase
  • bifunctional enzymes
  • c-methyltransferase
  • glycosyltransferase
  • mithramycin

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

Cite this