Cultures of Candida glabrata treated with CdCl2 form intracellular Cd(II) complexes that evolve with the time of culturing. Initially, glutathione (γECG) appears to be the major buffering component. One type of Cd(II)-glutathione complex exists as a cadmium:sulfide (CdS) crystallite coated with glutathione. A time dependent change in the coating of the CdS particles occurs with a decrease in the (γECG) content and a corresponding increase in the abundance of (γEC)nG peptides with (γEC)2G becoming the predominant peptide. The desGly variant (γEC)2 appears in significant concentration only in late cultures. The evolution in isopeptide coating appears to be dependent on the sulfide content of the CdS particles. Cellular conditions that enhance the generation of sulfide ions facilitate the conversion from γECG to (γEC)2G.
|Original language||English (US)|
|Number of pages||11|
|Journal||Journal of Inorganic Biochemistry|
|State||Published - Nov 1 1992|
ASJC Scopus subject areas
- Inorganic Chemistry