Abstract
This commentary is a reply to a recent article by Mahmood commenting on the authors' article on the use of fixed-exponent allometry in predicting human clearance. The commentary discusses eight issues that are related to criticisms made in Mahmood's article and examines the controversies (fixed-exponent vs. varying-exponent allometry) from the perspective of statistics and mathematics. The key conclusion is that any allometric method, which is to establish a power function based on a limited number of animal species and to extrapolate the resulting power function to human values (varying-exponent allometry), is infused with fundamental statistical errors.
Original language | English (US) |
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Pages (from-to) | 402-410 |
Number of pages | 9 |
Journal | Journal of pharmaceutical sciences |
Volume | 100 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2011 |
Externally published | Yes |
Keywords
- Allometry
- Clearance
- Fixed-exponent allometry
- PK predictions
- Varying-exponent allometry
ASJC Scopus subject areas
- Pharmaceutical Science