Controlled delivery of pilocarpine. 2. In-vivo evaluation of Gelfoam® device

P. Simamora, S. R. Nadkarni, Y. C. Lee, S. H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


In this report, an ocular device for the controlled delivery of pilocarpine was evaluated in albino rabbits using miosis as a bioassay for efficacy. The device was fabricated using Gelfoam® (absorbable gelatin sponge, USP) in the form of a matrix system. The efficacy of the device was compared in a cross-over study to the two conventional ophthalmic pilocarpine dosage forms, the eyedrop and the gel. The in-vivo results show that the gelfoam device is more effective than the two conventional pilocarpine dosage forms in prolonging the duration of the pilocarpine activity. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalInternational Journal of Pharmaceutics
Issue number2
StatePublished - Aug 15 1998


  • Controlled delivery
  • Gelfoam
  • Ocular device
  • Pilocarpine

ASJC Scopus subject areas

  • Pharmaceutical Science


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