Control of hemorrhage during renal failure with triglycyl-lysine- vasopressin

W. L. Garner, J. L. Rodriguez, P. D. Thomson, F. C. Brosius, D. J. Smith

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A 35-year-old man with chronic renal failure developed toxic epidermal necrolysis due to combination antibiotic therapy for a community acquired pneumonia. During wound care for his toxic epidermal necrolysis, he developed massive bleeding, a 4 to 6 unit blood loss at each dressing change, due to uremia-associated platelet dysfunction and thrombocytopenia. After failure of standard therapy, the man was treated with intravenous triglycyl-lysine- vasopressin, a selective peripheral vasoconstrictor. Transfusion requirements stopped during treatment. This man went on to full recovery with complete wound healing. Triglycyl-lysine-vasopressin effectively reduced skin blood loss in this man with toxic epidermal necrolysis and an intrinsic hemostatic defect, and may be useful in other patients with cutaneous blood loss.

Original languageEnglish (US)
Pages (from-to)78-81
Number of pages4
JournalAnnals of Plastic Surgery
Issue number1
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Control of hemorrhage during renal failure with triglycyl-lysine- vasopressin'. Together they form a unique fingerprint.

Cite this