Abstract
The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.
Original language | English (US) |
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Pages (from-to) | 2447-2450 |
Number of pages | 4 |
Journal | Journal of virology |
Volume | 74 |
Issue number | 5 |
DOIs | |
State | Published - 2000 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology