Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system

Beatriz Parra; Mark T. Lin; Stephen A. Stohlman; Cornelia C. Bergmann; Roscoe Atkinson; David R. Hinton

doi:10.1128/JVI.74.5.2447-2450.2000

Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system

Beatriz Parra, Mark T. Lin, Stephen A. Stohlman, Cornelia C. Bergmann, Roscoe Atkinson, David R. Hinton

Medicine

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.

Original language	English (US)
Pages (from-to)	2447-2450
Number of pages	4
Journal	Journal of virology
Volume	74
Issue number	5
DOIs	https://doi.org/10.1128/JVI.74.5.2447-2450.2000
State	Published - 2000

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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abstract = "The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.",

author = "Beatriz Parra and Lin, {Mark T.} and Stohlman, {Stephen A.} and Bergmann, {Cornelia C.} and Roscoe Atkinson and Hinton, {David R.}",

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AU - Parra, Beatriz

AU - Lin, Mark T.

AU - Stohlman, Stephen A.

AU - Bergmann, Cornelia C.

AU - Atkinson, Roscoe

AU - Hinton, David R.

PY - 2000

Y1 - 2000

N2 - The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.

AB - The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.

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Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system

Abstract

ASJC Scopus subject areas

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