Contrast-induced nephropathy: A review

Mohammad Sanaei-Ardekani, Mohammad Reza Movahed, Shahrzad Movafagh, Nasrollah Ghahramani

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Contrast-induced nephropathy (CIN) is one of the leading causes of renal impairment in the United States and the third cause of hospital-acquired renal failure. Reduction in the incidence of CIN can lead to a decrease in the morbidity, mortality, and length of hospital stay. Although prophylactic hydration has been promising in decreasing the occurrence of CIN, other efforts such as diuretics, calcium channel blockers, theophylline, aminophylline, atrial natriuretic peptide, dopamine, and fenoldopam have been disappointing. The preventive effect of N-acetylcysteine on CIN has not been consistent in the literature. In a recent clinical trial, bicarbonate infusion was more effective than hydration in the prevention of CIN. Mechanical devices are in development to perfuse renal arteries with protective drugs during contrast exposure or for removal of contrast from coronary sinus during coronary angiography. In this article, we have reviewed available data in regards to CIN.

Original languageEnglish (US)
Pages (from-to)82-88
Number of pages7
JournalCardiovascular Revascularization Medicine
Issue number2
StatePublished - 2005


  • Bicarbonate infusion
  • CIN
  • N-Acetylcysteine
  • Prophylactic hydration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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