Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity.

J. Vágner; P. Kocna; V. Krchnák

Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity.

J. Vágner, P. Kocna, V. Krchnák

Research output: Contribution to journal › Article › peer-review

Abstract

Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.

Original language	English (US)
Pages (from-to)	284-288
Number of pages	5
Journal	Peptide research
Volume	4
Issue number	5
State	Published - 1991

ASJC Scopus subject areas

Biochemistry
Endocrinology

Cite this

@article{9c27c95b4a7e4917ae7786d63da2e784,

title = "Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity.",

abstract = "Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.",

author = "J. V{\'a}gner and P. Kocna and V. Krchn{\'a}k",

year = "1991",

language = "English (US)",

volume = "4",

pages = "284--288",

journal = "Peptide Research",

issn = "1040-5704",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity.

AU - Vágner, J.

AU - Kocna, P.

AU - Krchnák, V.

PY - 1991

Y1 - 1991

N2 - Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.

AB - Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.

UR - http://www.scopus.com/inward/record.url?scp=0026216289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026216289&partnerID=8YFLogxK

M3 - Article

C2 - 1839365

AN - SCOPUS:0026216289

SN - 1040-5704

VL - 4

SP - 284

EP - 288

JO - Peptide Research

JF - Peptide Research

IS - 5

ER -

Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this