Continuous-flow solid-phase peptide synthesis

Viktor Krchňák; Josef Vágner; Martin Flegel; Otakar Mach

doi:10.1016/S0040-4039(00)96541-9

Continuous-flow solid-phase peptide synthesis

Viktor Krchňák, Josef Vágner, Martin Flegel, Otakar Mach

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.

Original language	English (US)
Pages (from-to)	4469-4472
Number of pages	4
Journal	Tetrahedron Letters
Volume	28
Issue number	38
DOIs	https://doi.org/10.1016/S0040-4039(00)96541-9
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)96541-9

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@article{40e04e4435374caab49b5737d6b47231,

title = "Continuous-flow solid-phase peptide synthesis",

abstract = "We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.",

author = "Viktor Krch{\v n}{\'a}k and Josef V{\'a}gner and Martin Flegel and Otakar Mach",

year = "1987",

doi = "10.1016/S0040-4039(00)96541-9",

language = "English (US)",

volume = "28",

pages = "4469--4472",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "38",

}

TY - JOUR

T1 - Continuous-flow solid-phase peptide synthesis

AU - Krchňák, Viktor

AU - Vágner, Josef

AU - Flegel, Martin

AU - Mach, Otakar

PY - 1987

Y1 - 1987

N2 - We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.

AB - We describe a simple manually operated synthesizer for solid-phase peptide synthesis (SPPS). The synthesis is performed on standard polystyrene-based resin in a flow reactor under low-pressure conditions. The usefulness of the present configuration of SPPS is exemplified on the synthesis of two octapeptide and one decapeptide amides.

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UR - http://www.scopus.com/inward/citedby.url?scp=4243336683&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)96541-9

DO - 10.1016/S0040-4039(00)96541-9

M3 - Article

AN - SCOPUS:4243336683

SN - 0040-4039

VL - 28

SP - 4469

EP - 4472

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

Continuous-flow solid-phase peptide synthesis

Abstract

ASJC Scopus subject areas

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