Construction of an all-carbon quaternary stereocenter by organocatalytic enantioselective α-functionalization of α-substituted β-ketocarbonyls with electron deficient vinylarenes

Shizhou Liu, Mengchao Tong, Yang Yu, Hexin Xie, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A chiral amine catalyzed enantioselective α-functionalization of α-substituted β-ketocarbonyls with electron-deficient vinylarenes has been developed to construct the dicarbonyl products with the formation of a chiral all-carbon quaternary stereocenter. The products can be used for the efficient synthesis of useful but challenging chiral quaternary centered pyrazolones.

Original languageEnglish (US)
Pages (from-to)11221-11224
Number of pages4
JournalChemical Communications
Volume51
Issue number56
DOIs
StatePublished - Jul 18 2015
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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