Abstract
What will it take to develop interventions for the treatment of age-related cognitive decline? Session V of the Summit provided perspectives on the design of clinical trials to evaluate promising but unproven interventions, and some of the steps needed to accelerate the discovery and evaluation of promising treatments. It considered strategies to further characterize the biological and cognitive changes associated with normal aging and their translation into the development of new treatments. It provided regulatory, scientific, and clinical perspectives about neurocognitive aging treatments, their potential benefits and risks, and the strategies and endpoints needed to evaluate them in the most rapid, rigorous, and clinically meaningful way. It considered lessons learned from the study of Alzheimer's disease, the promising roles of biomarkers in neurocognitive aging research, and ways to help galvanize the scientific study and treatment of neurocognitive aging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 766-772 |
| Number of pages | 7 |
| Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
| Volume | 67 A |
| Issue number | 7 |
| DOIs | |
| State | Published - Jun 15 2012 |
| Externally published | Yes |
Keywords
- Aging
- Clinical trials
- Cognition
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology