Conformation of two somatostatin analogues in aqueous solution: Study by NMR methods and circular dichroism

Chantal WYNANTS; Dirk TOURWE; Wieslaw KAZMIERSKI; Victor J. HRUBY; Georges VAN BINST

doi:10.1111/j.1432-1033.1989.tb15125.x

Conformation of two somatostatin analogues in aqueous solution: Study by NMR methods and circular dichroism

Chantal WYNANTS, Dirk TOURWE, Wieslaw KAZMIERSKI, Victor J. HRUBY, Georges VAN BINST

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Cyclic‐disulfide‐containing analogues of somatostatin, [Xaa¹= H or DPhe; Xaa³= Phe or Tyr; Xaa⁷= Cys, Me₂Cys or Me₂DCys; Xaa⁸= OH, Thr⁸ (OH) or Thr⁸NH₂], were examined in aqueous solution by ¹H‐NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.

Original language	English (US)
Pages (from-to)	371-381
Number of pages	11
Journal	European Journal of Biochemistry
Volume	185
Issue number	2
DOIs	https://doi.org/10.1111/j.1432-1033.1989.tb15125.x
State	Published - Nov 1989

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1432-1033.1989.tb15125.x

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abstract = "Cyclic‐disulfide‐containing analogues of somatostatin, [Xaa1= H or DPhe; Xaa3= Phe or Tyr; Xaa7= Cys, Me2Cys or Me2DCys; Xaa8= OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H‐NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.",

author = "Chantal WYNANTS and Dirk TOURWE and Wieslaw KAZMIERSKI and HRUBY, {Victor J.} and {VAN BINST}, Georges",

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language = "English (US)",

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T2 - Study by NMR methods and circular dichroism

AU - WYNANTS, Chantal

AU - TOURWE, Dirk

AU - KAZMIERSKI, Wieslaw

AU - HRUBY, Victor J.

AU - VAN BINST, Georges

PY - 1989/11

Y1 - 1989/11

N2 - Cyclic‐disulfide‐containing analogues of somatostatin, [Xaa1= H or DPhe; Xaa3= Phe or Tyr; Xaa7= Cys, Me2Cys or Me2DCys; Xaa8= OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H‐NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.

AB - Cyclic‐disulfide‐containing analogues of somatostatin, [Xaa1= H or DPhe; Xaa3= Phe or Tyr; Xaa7= Cys, Me2Cys or Me2DCys; Xaa8= OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H‐NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.

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Conformation of two somatostatin analogues in aqueous solution: Study by NMR methods and circular dichroism

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