TY - JOUR
T1 - Conformation of two somatostatin analogues in aqueous solution
T2 - Study by NMR methods and circular dichroism
AU - WYNANTS, Chantal
AU - TOURWE, Dirk
AU - KAZMIERSKI, Wieslaw
AU - HRUBY, Victor J.
AU - VAN BINST, Georges
PY - 1989/11
Y1 - 1989/11
N2 - Cyclic‐disulfide‐containing analogues of somatostatin, [Xaa1= H or DPhe; Xaa3= Phe or Tyr; Xaa7= Cys, Me2Cys or Me2DCys; Xaa8= OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H‐NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.
AB - Cyclic‐disulfide‐containing analogues of somatostatin, [Xaa1= H or DPhe; Xaa3= Phe or Tyr; Xaa7= Cys, Me2Cys or Me2DCys; Xaa8= OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H‐NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.
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U2 - 10.1111/j.1432-1033.1989.tb15125.x
DO - 10.1111/j.1432-1033.1989.tb15125.x
M3 - Article
C2 - 2573530
AN - SCOPUS:0024463892
SN - 0014-2956
VL - 185
SP - 371
EP - 381
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
IS - 2
ER -