Conformal piezoelectric systems for clinical and experimental characterization of soft tissue biomechanics

Canan Dagdeviren, Yan Shi, Pauline Joe, Roozbeh Ghaffari, Guive Balooch, Karan Usgaonkar, Onur Gur, Phat L. Tran, Jessi R. Crosby, Marcin Meyer, Yewang Su, R. Chad Webb, Andrew S. Tedesco, Marvin J. Slepian, Yonggang Huang, John A. Rogers

Research output: Contribution to journalArticlepeer-review

393 Scopus citations


Mechanical assessment of soft biological tissues and organs has broad relevance in clinical diagnosis and treatment of disease. Existing characterization methods are invasive, lack microscale spatial resolution, and are tailored only for specific regions of the body under quasi-static conditions. Here, we develop conformal and piezoelectric devices that enable in vivo measurements of soft tissue viscoelasticity in the near-surface regions of the epidermis. These systems achieve conformal contact with the underlying complex topography and texture of the targeted skin, as well as other organ surfaces, under both quasi-static and dynamic conditions. Experimental and theoretical characterization of the responses of piezoelectric actuator-sensor pairs laminated on a variety of soft biological tissues and organ systems in animal models provide information on the operation of the devices. Studies on human subjects establish the clinical significance of these devices for rapid and non-invasive characterization of skin mechanical properties.

Original languageEnglish (US)
Pages (from-to)728-736
Number of pages9
JournalNature materials
Issue number7
StatePublished - Jul 24 2015

ASJC Scopus subject areas

  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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