Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Pavel Nagorny; Isaac Krauss; Jón T. Njardarson; Lucy Perez; Christoph Gaul; Guangli Yang; Ouathek Ouerfelli; Samuel J. Danishefsky

doi:10.1016/j.tetlet.2010.05.056

Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Pavel Nagorny
, Isaac Krauss
, Jón T. Njardarson
, Lucy Perez
, Christoph Gaul
, Guangli Yang
, Ouathek Ouerfelli
, Samuel J. Danishefsky

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.

Original language	English (US)
Pages (from-to)	3873-3875
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2010.05.056
State	Published - Jul 28 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.05.056

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title = "Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims",

abstract = "In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.",

author = "Pavel Nagorny and Isaac Krauss and Njardarson, \{J{\'o}n T.\} and Lucy Perez and Christoph Gaul and Guangli Yang and Ouathek Ouerfelli and Danishefsky, \{Samuel J.\}",

note = "Funding Information: This work was supported by NIH Grant CA103823 (S.J.D.). P.N. thanks the National Institutes of Health for a Ruth L. Kirschstein postdoctoral fellowship (CA125934-02). PN thanks Dr. Neeraj Sane for useful discussions. ",

year = "2010",

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doi = "10.1016/j.tetlet.2010.05.056",

language = "English (US)",

volume = "51",

pages = "3873--3875",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

AU - Nagorny, Pavel

AU - Krauss, Isaac

AU - Njardarson, Jón T.

AU - Perez, Lucy

AU - Gaul, Christoph

AU - Yang, Guangli

AU - Ouerfelli, Ouathek

AU - Danishefsky, Samuel J.

N1 - Funding Information: This work was supported by NIH Grant CA103823 (S.J.D.). P.N. thanks the National Institutes of Health for a Ruth L. Kirschstein postdoctoral fellowship (CA125934-02). PN thanks Dr. Neeraj Sane for useful discussions.

PY - 2010/7/28

Y1 - 2010/7/28

N2 - In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.

AB - In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.

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UR - https://www.scopus.com/pages/publications/77953811498#tab=citedBy

U2 - 10.1016/j.tetlet.2010.05.056

DO - 10.1016/j.tetlet.2010.05.056

M3 - Article

AN - SCOPUS:77953811498

SN - 0040-4039

VL - 51

SP - 3873

EP - 3875

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 30

ER -

Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Abstract

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