Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Pavel Nagorny; Isaac Krauss; Jón T. Njardarson; Lucy Perez; Christoph Gaul; Guangli Yang; Ouathek Ouerfelli; Samuel J. Danishefsky

doi:10.1016/j.tetlet.2010.05.056

Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Pavel Nagorny, Isaac Krauss, Jón T. Njardarson, Lucy Perez, Christoph Gaul, Guangli Yang, Ouathek Ouerfelli, Samuel J. Danishefsky

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.

Original language	English (US)
Pages (from-to)	3873-3875
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2010.05.056
State	Published - Jul 28 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2010.05.056

Cite this

@article{894f5bd50f48435cb03181b590b0e744,

title = "Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims",

abstract = "In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.",

author = "Pavel Nagorny and Isaac Krauss and Njardarson, {J{\'o}n T.} and Lucy Perez and Christoph Gaul and Guangli Yang and Ouathek Ouerfelli and Danishefsky, {Samuel J.}",

note = "Funding Information: This work was supported by NIH Grant CA103823 (S.J.D.). P.N. thanks the National Institutes of Health for a Ruth L. Kirschstein postdoctoral fellowship (CA125934-02). PN thanks Dr. Neeraj Sane for useful discussions. ",

year = "2010",

month = jul,

day = "28",

doi = "10.1016/j.tetlet.2010.05.056",

language = "English (US)",

volume = "51",

pages = "3873--3875",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "30",

}

TY - JOUR

T1 - Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

AU - Nagorny, Pavel

AU - Krauss, Isaac

AU - Njardarson, Jón T.

AU - Perez, Lucy

AU - Gaul, Christoph

AU - Yang, Guangli

AU - Ouerfelli, Ouathek

AU - Danishefsky, Samuel J.

N1 - Funding Information: This work was supported by NIH Grant CA103823 (S.J.D.). P.N. thanks the National Institutes of Health for a Ruth L. Kirschstein postdoctoral fellowship (CA125934-02). PN thanks Dr. Neeraj Sane for useful discussions.

PY - 2010/7/28

Y1 - 2010/7/28

N2 - In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.

AB - In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.

UR - http://www.scopus.com/inward/record.url?scp=77953811498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953811498&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2010.05.056

DO - 10.1016/j.tetlet.2010.05.056

M3 - Article

AN - SCOPUS:77953811498

SN - 0040-4039

VL - 51

SP - 3873

EP - 3875

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 30

ER -

Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this