Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data

Obaid M. Al-Saidy; Walter W. Piegorsch; R. Webster West; Daniela K. Nitcheva

doi:10.1111/j.0006-341X.2003.00121.x

Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data

Obaid M. Al-Saidy
, Walter W. Piegorsch
, R. Webster West
, Daniela K. Nitcheva

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

Original language	English (US)
Pages (from-to)	1056-1062
Number of pages	7
Journal	Biometrics
Volume	59
Issue number	4
DOIs	https://doi.org/10.1111/j.0006-341X.2003.00121.x
State	Published - Dec 2003
Externally published	Yes

Keywords

Benchmark analysis
Benchmark dose
Carcinogenic risk assessment
Low-dose extrapolation
Multistage model
Quantal data
Quantitative risk analysis
Simultaneous confidence bounds
Toxicology

ASJC Scopus subject areas

Statistics and Probability
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

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10.1111/j.0006-341X.2003.00121.x

Cite this

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title = "Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data",

abstract = "We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.",

keywords = "Benchmark analysis, Benchmark dose, Carcinogenic risk assessment, Low-dose extrapolation, Multistage model, Quantal data, Quantitative risk analysis, Simultaneous confidence bounds, Toxicology",

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AU - Al-Saidy, Obaid M.

AU - Piegorsch, Walter W.

AU - West, R. Webster

AU - Nitcheva, Daniela K.

PY - 2003/12

Y1 - 2003/12

N2 - We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

AB - We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

KW - Benchmark analysis

KW - Benchmark dose

KW - Carcinogenic risk assessment

KW - Low-dose extrapolation

KW - Multistage model

KW - Quantal data

KW - Quantitative risk analysis

KW - Simultaneous confidence bounds

KW - Toxicology

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M3 - Article

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AN - SCOPUS:0346102885

SN - 0006-341X

VL - 59

SP - 1056

EP - 1062

JO - Biometrics

JF - Biometrics

IS - 4

ER -

Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data

Abstract

Keywords

ASJC Scopus subject areas

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