Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data

Obaid M. Al-Saidy; Walter W. Piegorsch; R. Webster West; Daniela K. Nitcheva

doi:10.1111/j.0006-341X.2003.00121.x

Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data

Obaid M. Al-Saidy, Walter W. Piegorsch, R. Webster West, Daniela K. Nitcheva

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

Original language	English (US)
Pages (from-to)	1056-1062
Number of pages	7
Journal	Biometrics
Volume	59
Issue number	4
DOIs	https://doi.org/10.1111/j.0006-341X.2003.00121.x
State	Published - Dec 2003

Keywords

Benchmark analysis
Benchmark dose
Carcinogenic risk assessment
Low-dose extrapolation
Multistage model
Quantal data
Quantitative risk analysis
Simultaneous confidence bounds
Toxicology

ASJC Scopus subject areas

Statistics and Probability
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

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10.1111/j.0006-341X.2003.00121.x

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title = "Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data",

abstract = "We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.",

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AU - Al-Saidy, Obaid M.

AU - Piegorsch, Walter W.

AU - West, R. Webster

AU - Nitcheva, Daniela K.

PY - 2003/12

Y1 - 2003/12

N2 - We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

AB - We study the use of simultaneous confidence bands for low-dose risk estimation with quantal response data, and derive methods for estimating simultaneous upper confidence limits on predicted extra risk under a multistage model. By inverting the upper bands on extra risk, we obtain simultaneous lower bounds on the benchmark dose (BMD). Monte Carlo evaluations explore characteristics of the simultaneous limits under this setting, and a suite of actual data sets are used to compare existing methods for placing lower limits on the BMD.

KW - Benchmark analysis

KW - Benchmark dose

KW - Carcinogenic risk assessment

KW - Low-dose extrapolation

KW - Multistage model

KW - Quantal data

KW - Quantitative risk analysis

KW - Simultaneous confidence bounds

KW - Toxicology

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Confidence Bands for Low-Dose Risk Estimation with Quantal Response Data

Abstract

Keywords

ASJC Scopus subject areas

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