Abstract
Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enables ring-closing transformations. The protocols are further facilitated by the use of microwave irradiation and n-butyl isocyanide to control the rate of each ring-forming transformation.
Original language | English (US) |
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Pages (from-to) | 3951-3955 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 30 |
DOIs | |
State | Published - Jul 28 2010 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry