Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles

Steven Gunawan; Joachim Petit; Christopher Hulme

doi:10.1021/co200209a

Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles

Steven Gunawan, Joachim Petit, Christopher Hulme

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.

Original language	English (US)
Pages (from-to)	160-163
Number of pages	4
Journal	ACS Combinatorial Science
Volume	14
Issue number	3
DOIs	https://doi.org/10.1021/co200209a
State	Published - Mar 12 2012

Keywords

1,5-disubstituted tetrazoles
Ugi reaction

ASJC Scopus subject areas

General Chemistry

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10.1021/co200209a

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abstract = "A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.",

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AB - A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.

KW - 1,5-disubstituted tetrazoles

KW - Ugi reaction

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Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles

Abstract

Keywords

ASJC Scopus subject areas

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