Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus

J. M. Fellous; P. H.E. Tiesinga; J. V. José; T. J. Sejnowski

doi:10.1016/S0925-2312(01)00422-2

Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus

J. M. Fellous, P. H.E. Tiesinga, J. V. José, T. J. Sejnowski

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Application of carbachol (cch) can induce oscillations in the δ (cch-δ, 0.5-2 Hz), θ (cch-θ, 4-12 Hz), and γ (cch-γ, 30-80 Hz) frequency-range in the rat hippocampal slice preparation. Using model CA3 cells we found that the time scale for cch-δ was determined by the decay constant of I_K-AHP, that of cch-θ by an intrinsic subthreshold membrane potential oscillation, and that of cch-γ by the decay constant of GABA-ergic postsynaptic potentials. The known physiological effects of carbachol on I_M, and I_K-AHP, and on the strength of excitatory postsynaptic potentials produced the observed transitions from incoherent cch-θ to cch-δ, and from cch-δ to cch-θ with increasing cch concentrations, as well as the nested cch-γ-δ and cch-γ-θ seen in experiment.

Original language	English (US)
Pages (from-to)	587-593
Number of pages	7
Journal	Neurocomputing
Volume	38-40
DOIs	https://doi.org/10.1016/S0925-2312(01)00422-2
State	Published - Jun 2001
Externally published	Yes

Keywords

Biophysical model
Neuromodulator
Oscillation
Synchrony

ASJC Scopus subject areas

Computer Science Applications
Cognitive Neuroscience
Artificial Intelligence

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10.1016/S0925-2312(01)00422-2

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@article{6ca0f5fd28ed41b3b30951e3382efb2b,

title = "Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus",

abstract = "Application of carbachol (cch) can induce oscillations in the δ (cch-δ, 0.5-2 Hz), θ (cch-θ, 4-12 Hz), and γ (cch-γ, 30-80 Hz) frequency-range in the rat hippocampal slice preparation. Using model CA3 cells we found that the time scale for cch-δ was determined by the decay constant of IK-AHP, that of cch-θ by an intrinsic subthreshold membrane potential oscillation, and that of cch-γ by the decay constant of GABA-ergic postsynaptic potentials. The known physiological effects of carbachol on IM, and IK-AHP, and on the strength of excitatory postsynaptic potentials produced the observed transitions from incoherent cch-θ to cch-δ, and from cch-δ to cch-θ with increasing cch concentrations, as well as the nested cch-γ-δ and cch-γ-θ seen in experiment.",

keywords = "Biophysical model, Neuromodulator, Oscillation, Synchrony",

author = "Fellous, {J. M.} and Tiesinga, {P. H.E.} and Jos{\'e}, {J. V.} and Sejnowski, {T. J.}",

note = "Funding Information: This work was supported by the Sloan Center for Theoretical Neurobiology at the Salk Institute, the Howard Hughes Medical Institute, and by the Center for Interdisciplinary Research on Complex Systems (CIRCS) funded by Northeastern University. ",

year = "2001",

month = jun,

doi = "10.1016/S0925-2312(01)00422-2",

language = "English (US)",

volume = "38-40",

pages = "587--593",

journal = "Neurocomputing",

issn = "0925-2312",

publisher = "Elsevier",

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TY - JOUR

T1 - Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus

AU - Fellous, J. M.

AU - Tiesinga, P. H.E.

AU - José, J. V.

AU - Sejnowski, T. J.

N1 - Funding Information: This work was supported by the Sloan Center for Theoretical Neurobiology at the Salk Institute, the Howard Hughes Medical Institute, and by the Center for Interdisciplinary Research on Complex Systems (CIRCS) funded by Northeastern University.

PY - 2001/6

Y1 - 2001/6

N2 - Application of carbachol (cch) can induce oscillations in the δ (cch-δ, 0.5-2 Hz), θ (cch-θ, 4-12 Hz), and γ (cch-γ, 30-80 Hz) frequency-range in the rat hippocampal slice preparation. Using model CA3 cells we found that the time scale for cch-δ was determined by the decay constant of IK-AHP, that of cch-θ by an intrinsic subthreshold membrane potential oscillation, and that of cch-γ by the decay constant of GABA-ergic postsynaptic potentials. The known physiological effects of carbachol on IM, and IK-AHP, and on the strength of excitatory postsynaptic potentials produced the observed transitions from incoherent cch-θ to cch-δ, and from cch-δ to cch-θ with increasing cch concentrations, as well as the nested cch-γ-δ and cch-γ-θ seen in experiment.

AB - Application of carbachol (cch) can induce oscillations in the δ (cch-δ, 0.5-2 Hz), θ (cch-θ, 4-12 Hz), and γ (cch-γ, 30-80 Hz) frequency-range in the rat hippocampal slice preparation. Using model CA3 cells we found that the time scale for cch-δ was determined by the decay constant of IK-AHP, that of cch-θ by an intrinsic subthreshold membrane potential oscillation, and that of cch-γ by the decay constant of GABA-ergic postsynaptic potentials. The known physiological effects of carbachol on IM, and IK-AHP, and on the strength of excitatory postsynaptic potentials produced the observed transitions from incoherent cch-θ to cch-δ, and from cch-δ to cch-θ with increasing cch concentrations, as well as the nested cch-γ-δ and cch-γ-θ seen in experiment.

KW - Biophysical model

KW - Neuromodulator

KW - Oscillation

KW - Synchrony

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EP - 593

JO - Neurocomputing

JF - Neurocomputing

ER -

Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus

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Keywords

ASJC Scopus subject areas

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