Application of carbachol (cch) can induce oscillations in the δ (cch-δ, 0.5-2 Hz), θ (cch-θ, 4-12 Hz), and γ (cch-γ, 30-80 Hz) frequency-range in the rat hippocampal slice preparation. Using model CA3 cells we found that the time scale for cch-δ was determined by the decay constant of IK-AHP, that of cch-θ by an intrinsic subthreshold membrane potential oscillation, and that of cch-γ by the decay constant of GABA-ergic postsynaptic potentials. The known physiological effects of carbachol on IM, and IK-AHP, and on the strength of excitatory postsynaptic potentials produced the observed transitions from incoherent cch-θ to cch-δ, and from cch-δ to cch-θ with increasing cch concentrations, as well as the nested cch-γ-δ and cch-γ-θ seen in experiment.
- Biophysical model
ASJC Scopus subject areas
- Computer Science Applications
- Cognitive Neuroscience
- Artificial Intelligence