Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus

J. M. Fellous, P. H.E. Tiesinga, J. V. José, T. J. Sejnowski

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Application of carbachol (cch) can induce oscillations in the δ (cch-δ, 0.5-2 Hz), θ (cch-θ, 4-12 Hz), and γ (cch-γ, 30-80 Hz) frequency-range in the rat hippocampal slice preparation. Using model CA3 cells we found that the time scale for cch-δ was determined by the decay constant of IK-AHP, that of cch-θ by an intrinsic subthreshold membrane potential oscillation, and that of cch-γ by the decay constant of GABA-ergic postsynaptic potentials. The known physiological effects of carbachol on IM, and IK-AHP, and on the strength of excitatory postsynaptic potentials produced the observed transitions from incoherent cch-θ to cch-δ, and from cch-δ to cch-θ with increasing cch concentrations, as well as the nested cch-γ-δ and cch-γ-θ seen in experiment.

Original languageEnglish (US)
Pages (from-to)587-593
Number of pages7
StatePublished - Jun 2001


  • Biophysical model
  • Neuromodulator
  • Oscillation
  • Synchrony

ASJC Scopus subject areas

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence


Dive into the research topics of 'Computational model of carbachol-induced δ, θ and γ-like oscillations in hippocampus'. Together they form a unique fingerprint.

Cite this