Comparison of type-specific human papillomavirus data from self and clinician directed sampling

Susie Baldwin, Carlos Santos, Elena Mendez Brown, Thomas Nuño, Anna Giuliano, John Davis, Francisco Garcia

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Objective(s). To compare the type-specific human papillomavirus (HPV) recovery from physician and patient-collected samples. Methods. Three hundred thirty-four (334) women attending colposcopy clinics in three countries were enrolled in this cross-sectional study. Cervicovaginal samples were collected by patients and physicians and processed with polymerase chain reaction and reverse line blot genotyping. McNemar's Chi-squared tests and Kappa statistics were utilized to determine statistical associations between physician- versus patient-collected samples. Results. Oncogenic HPV infection was identified in 23.2% of patient-collected specimens compared to 34.9% of physician-collected specimens. Physician sampling detected significantly more infections with type 16 and 52 than did self-sampling and significantly more oncogenic HPV infection overall. For non-oncogenic HPV detection, there was no statistical difference between physician- and patient-collected samples. Conclusion(s). Patient sampling for HPV using a single vaginal brush does not identify all oncogenic HPV subtypes.

Original languageEnglish (US)
Pages (from-to)612-617
Number of pages6
JournalGynecologic oncology
Issue number2
StatePublished - May 2005


  • Cervical cancer
  • Clinician directed sampling
  • Human papillomavirus
  • Self-sampling

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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