Comparison of the Host Ranges and Antigenicity of Cryptosporidium parvum and Cryptosporidium wrairi from Guinea Pigs

CLARENCE E. CHRISP; MARK A. SUCKOW; RONALD FAYER; MICHAEL J. ARROWOOD; MARK C. HEALEY; CHARLES R. STERLING

doi:10.1111/j.1550-7408.1992.tb01471.x

Comparison of the Host Ranges and Antigenicity of Cryptosporidium parvum and Cryptosporidium wrairi from Guinea Pigs

CLARENCE E. CHRISP, MARK A. SUCKOW, RONALD FAYER, MICHAEL J. ARROWOOD, MARK C. HEALEY, CHARLES R. STERLING

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

ABSTRACT. Oocysts of a Cryptosporidium isolate from guinea pigs were not infectious for adult mice, but were infectious for two of three newborn calves and for suckling mice. However, oocysts isolated from calves or mice infected with guinea pig Cryptosporidium were not infectious for guinea pigs. Four isolates of C. parvum from calves were incapable of infecting weanling guinea pigs. Microscopic examination of tissue from the colon and cecum of suckling guinea pigs inoculated with C. parvum revealed sparse infection of some pups. These host range studies and previously described differences in ¹²⁵I‐labeled oocyst surface protein profiles between Cryptosporidium sp. from guinea pigs and C. parvum suggest they are distinct species. We propose the name Cryptosporidium wrairi be retained. Studies with monoclonal antibodies indicate that C. wrairi and C. parvum are antigenically related.

Original language	English (US)
Pages (from-to)	406-409
Number of pages	4
Journal	The Journal of protozoology
Volume	39
Issue number	3
DOIs	https://doi.org/10.1111/j.1550-7408.1992.tb01471.x
State	Published - May 1992

Keywords

Monoclonal antibodies
oocysts
sporozoites
transmission experiments

ASJC Scopus subject areas

Parasitology

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10.1111/j.1550-7408.1992.tb01471.x

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title = "Comparison of the Host Ranges and Antigenicity of Cryptosporidium parvum and Cryptosporidium wrairi from Guinea Pigs",

abstract = "ABSTRACT. Oocysts of a Cryptosporidium isolate from guinea pigs were not infectious for adult mice, but were infectious for two of three newborn calves and for suckling mice. However, oocysts isolated from calves or mice infected with guinea pig Cryptosporidium were not infectious for guinea pigs. Four isolates of C. parvum from calves were incapable of infecting weanling guinea pigs. Microscopic examination of tissue from the colon and cecum of suckling guinea pigs inoculated with C. parvum revealed sparse infection of some pups. These host range studies and previously described differences in 125I‐labeled oocyst surface protein profiles between Cryptosporidium sp. from guinea pigs and C. parvum suggest they are distinct species. We propose the name Cryptosporidium wrairi be retained. Studies with monoclonal antibodies indicate that C. wrairi and C. parvum are antigenically related.",

keywords = "Monoclonal antibodies, oocysts, sporozoites, transmission experiments",

author = "CHRISP, {CLARENCE E.} and SUCKOW, {MARK A.} and RONALD FAYER and ARROWOOD, {MICHAEL J.} and HEALEY, {MARK C.} and STERLING, {CHARLES R.}",

year = "1992",

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doi = "10.1111/j.1550-7408.1992.tb01471.x",

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AU - CHRISP, CLARENCE E.

AU - SUCKOW, MARK A.

AU - FAYER, RONALD

AU - ARROWOOD, MICHAEL J.

AU - HEALEY, MARK C.

AU - STERLING, CHARLES R.

PY - 1992/5

Y1 - 1992/5

N2 - ABSTRACT. Oocysts of a Cryptosporidium isolate from guinea pigs were not infectious for adult mice, but were infectious for two of three newborn calves and for suckling mice. However, oocysts isolated from calves or mice infected with guinea pig Cryptosporidium were not infectious for guinea pigs. Four isolates of C. parvum from calves were incapable of infecting weanling guinea pigs. Microscopic examination of tissue from the colon and cecum of suckling guinea pigs inoculated with C. parvum revealed sparse infection of some pups. These host range studies and previously described differences in 125I‐labeled oocyst surface protein profiles between Cryptosporidium sp. from guinea pigs and C. parvum suggest they are distinct species. We propose the name Cryptosporidium wrairi be retained. Studies with monoclonal antibodies indicate that C. wrairi and C. parvum are antigenically related.

AB - ABSTRACT. Oocysts of a Cryptosporidium isolate from guinea pigs were not infectious for adult mice, but were infectious for two of three newborn calves and for suckling mice. However, oocysts isolated from calves or mice infected with guinea pig Cryptosporidium were not infectious for guinea pigs. Four isolates of C. parvum from calves were incapable of infecting weanling guinea pigs. Microscopic examination of tissue from the colon and cecum of suckling guinea pigs inoculated with C. parvum revealed sparse infection of some pups. These host range studies and previously described differences in 125I‐labeled oocyst surface protein profiles between Cryptosporidium sp. from guinea pigs and C. parvum suggest they are distinct species. We propose the name Cryptosporidium wrairi be retained. Studies with monoclonal antibodies indicate that C. wrairi and C. parvum are antigenically related.

KW - Monoclonal antibodies

KW - oocysts

KW - sporozoites

KW - transmission experiments

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Comparison of the Host Ranges and Antigenicity of Cryptosporidium parvum and Cryptosporidium wrairi from Guinea Pigs

Abstract

Keywords

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