Comparison of Serum Per- and Polyfluoroalkyl Substances Concentrations in Incumbent and Recruit Firefighters and Longitudinal Assessment in Recruits

Amy J. Nematollahi; Julia M. Fisher; Melissa A. Furlong; Paloma I. Beamer; Jaclyn M. Goodrich; Judith M. Graber; Antonia M. Calafat; Julianne Cook Botelho; Shawn C. Beitel; Sally R. Littau; John J. Gulotta; Darin D. Wallentine; Jefferey L. Burgess

doi:10.1097/JOM.0000000000003020

Comparison of Serum Per- and Polyfluoroalkyl Substances Concentrations in Incumbent and Recruit Firefighters and Longitudinal Assessment in Recruits

Amy J. Nematollahi, Julia M. Fisher, Melissa A. Furlong, Paloma I. Beamer, Jaclyn M. Goodrich, Judith M. Graber, Antonia M. Calafat, Julianne Cook Botelho, Shawn C. Beitel, Sally R. Littau, John J. Gulotta, Darin D. Wallentine, Jefferey L. Burgess

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Objective: Firefighters are occupationally exposed to per- and polyfluoroalkyl substances (PFAS). This study objective was to compare serum PFAS concentrations in incumbent and recruit firefighters and evaluate temporal trends among recruits. Methods: SerumPFAS concentrations weremeasured in 99 incumbent and 55 recruit firefighters at enrollment in 2015-2016, with follow-up 20 to 37 months later for recruits. Linear and logistic regression and linear mixed-effects models were used for analyses. Fireground exposure impact on PFAS concentrations was investigated using adjusted linear and logistic regression models. Results: Incumbents had lower n-PFOA and PFNA than recruits and most PFAS significantly decreased over time among male recruits. No significant links were found between cumulative fireground exposures and PFAS concentrations. Conclusions: Serum PFAS concentrations were not increased in incumbent firefighters compared with recruits and were not associated with cumulative fireground exposures.

Original language	English (US)
Pages (from-to)	202-211
Number of pages	10
Journal	Journal of occupational and environmental medicine
Volume	66
Issue number	3
DOIs	https://doi.org/10.1097/JOM.0000000000003020
State	Published - Mar 1 2024

Keywords

PFAS
vulnerable occupations
workplace exposures

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1097/JOM.0000000000003020

Cite this

Nematollahi, A. J., Fisher, J. M., Furlong, M. A., Beamer, P. I., Goodrich, J. M., Graber, J. M., Calafat, A. M., Botelho, J. C., Beitel, S. C., Littau, S. R., Gulotta, J. J., Wallentine, D. D., & Burgess, J. L. (2024). Comparison of Serum Per- and Polyfluoroalkyl Substances Concentrations in Incumbent and Recruit Firefighters and Longitudinal Assessment in Recruits. Journal of occupational and environmental medicine, 66(3), 202-211. https://doi.org/10.1097/JOM.0000000000003020

Comparison of Serum Per- and Polyfluoroalkyl Substances Concentrations in Incumbent and Recruit Firefighters and Longitudinal Assessment in Recruits. / Nematollahi, Amy J.; Fisher, Julia M.; Furlong, Melissa A. et al.
In: Journal of occupational and environmental medicine, Vol. 66, No. 3, 01.03.2024, p. 202-211.

Research output: Contribution to journal › Article › peer-review

Nematollahi, AJ, Fisher, JM , Furlong, MA , Beamer, PI, Goodrich, JM, Graber, JM, Calafat, AM, Botelho, JC, Beitel, SC, Littau, SR, Gulotta, JJ, Wallentine, DD & Burgess, JL 2024, 'Comparison of Serum Per- and Polyfluoroalkyl Substances Concentrations in Incumbent and Recruit Firefighters and Longitudinal Assessment in Recruits', Journal of occupational and environmental medicine, vol. 66, no. 3, pp. 202-211. https://doi.org/10.1097/JOM.0000000000003020

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abstract = "Objective: Firefighters are occupationally exposed to per- and polyfluoroalkyl substances (PFAS). This study objective was to compare serum PFAS concentrations in incumbent and recruit firefighters and evaluate temporal trends among recruits. Methods: SerumPFAS concentrations weremeasured in 99 incumbent and 55 recruit firefighters at enrollment in 2015-2016, with follow-up 20 to 37 months later for recruits. Linear and logistic regression and linear mixed-effects models were used for analyses. Fireground exposure impact on PFAS concentrations was investigated using adjusted linear and logistic regression models. Results: Incumbents had lower n-PFOA and PFNA than recruits and most PFAS significantly decreased over time among male recruits. No significant links were found between cumulative fireground exposures and PFAS concentrations. Conclusions: Serum PFAS concentrations were not increased in incumbent firefighters compared with recruits and were not associated with cumulative fireground exposures.",

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AU - Fisher, Julia M.

AU - Furlong, Melissa A.

AU - Beamer, Paloma I.

AU - Goodrich, Jaclyn M.

AU - Graber, Judith M.

AU - Calafat, Antonia M.

AU - Botelho, Julianne Cook

AU - Beitel, Shawn C.

AU - Littau, Sally R.

AU - Gulotta, John J.

AU - Wallentine, Darin D.

AU - Burgess, Jefferey L.

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N2 - Objective: Firefighters are occupationally exposed to per- and polyfluoroalkyl substances (PFAS). This study objective was to compare serum PFAS concentrations in incumbent and recruit firefighters and evaluate temporal trends among recruits. Methods: SerumPFAS concentrations weremeasured in 99 incumbent and 55 recruit firefighters at enrollment in 2015-2016, with follow-up 20 to 37 months later for recruits. Linear and logistic regression and linear mixed-effects models were used for analyses. Fireground exposure impact on PFAS concentrations was investigated using adjusted linear and logistic regression models. Results: Incumbents had lower n-PFOA and PFNA than recruits and most PFAS significantly decreased over time among male recruits. No significant links were found between cumulative fireground exposures and PFAS concentrations. Conclusions: Serum PFAS concentrations were not increased in incumbent firefighters compared with recruits and were not associated with cumulative fireground exposures.

AB - Objective: Firefighters are occupationally exposed to per- and polyfluoroalkyl substances (PFAS). This study objective was to compare serum PFAS concentrations in incumbent and recruit firefighters and evaluate temporal trends among recruits. Methods: SerumPFAS concentrations weremeasured in 99 incumbent and 55 recruit firefighters at enrollment in 2015-2016, with follow-up 20 to 37 months later for recruits. Linear and logistic regression and linear mixed-effects models were used for analyses. Fireground exposure impact on PFAS concentrations was investigated using adjusted linear and logistic regression models. Results: Incumbents had lower n-PFOA and PFNA than recruits and most PFAS significantly decreased over time among male recruits. No significant links were found between cumulative fireground exposures and PFAS concentrations. Conclusions: Serum PFAS concentrations were not increased in incumbent firefighters compared with recruits and were not associated with cumulative fireground exposures.

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Comparison of Serum Per- and Polyfluoroalkyl Substances Concentrations in Incumbent and Recruit Firefighters and Longitudinal Assessment in Recruits

Abstract

Keywords

ASJC Scopus subject areas

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