Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation

Juyoung Park; Heling Tong; Yixin Kang; Hongyu Miao; Lifeng Lin; Rina S. Fox; Ilknur Telkes; Geraldine Martorella; Hyochol Ahn

doi:10.1080/17581869.2024.2429943

Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation

Juyoung Park, Heling Tong, Yixin Kang, Hongyu Miao, Lifeng Lin, Rina S. Fox, Ilknur Telkes, Geraldine Martorella, Hyochol Ahn

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: The study compared responders and nonresponders to transcranial direct current stimulation (tDCS) regarding clinical pain outcomes in knee osteoarthritis (OA) patients. Patients and Methods/Materials: Sixty participants received home-based active tDCS, and clinical pain outcomes were compared between responders and nonresponders. Results: Latent class growth analyses classified 41 participants as responders and 19 as nonresponders. Responders showed significantly greater decreases in pain intensity from baseline to post intervention than nonresponders (p <.001). Participants with higher BMI (p =.02) and weight (p =.005) were more likely to respond, while no significant sociodemographic differences were found. Conclusions: Identifying characteristics of nonresponsive tDCS subgroups can tailor treatments for each group. Clinical trial registration: www.clinicaltrials.gov identifier is NCT04016272.

Original language	English (US)
Pages (from-to)	507-518
Number of pages	12
Journal	Pain Management
Volume	14
Issue number	9
DOIs	https://doi.org/10.1080/17581869.2024.2429943
State	Published - 2024
Externally published	Yes

Keywords

BMI
Knee osteoarthritis
older adults
responders to tDCS
transcranial direct current stimulation

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1080/17581869.2024.2429943

Cite this

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title = "Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation",

abstract = "Aim: The study compared responders and nonresponders to transcranial direct current stimulation (tDCS) regarding clinical pain outcomes in knee osteoarthritis (OA) patients. Patients and Methods/Materials: Sixty participants received home-based active tDCS, and clinical pain outcomes were compared between responders and nonresponders. Results: Latent class growth analyses classified 41 participants as responders and 19 as nonresponders. Responders showed significantly greater decreases in pain intensity from baseline to post intervention than nonresponders (p <.001). Participants with higher BMI (p =.02) and weight (p =.005) were more likely to respond, while no significant sociodemographic differences were found. Conclusions: Identifying characteristics of nonresponsive tDCS subgroups can tailor treatments for each group. Clinical trial registration: www.clinicaltrials.gov identifier is NCT04016272.",

keywords = "BMI, Knee osteoarthritis, older adults, responders to tDCS, transcranial direct current stimulation",

author = "Juyoung Park and Heling Tong and Yixin Kang and Hongyu Miao and Lifeng Lin and Fox, \{Rina S.\} and Ilknur Telkes and Geraldine Martorella and Hyochol Ahn",

note = "Publisher Copyright: {\textcopyright} 2024 Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2024",

doi = "10.1080/17581869.2024.2429943",

language = "English (US)",

volume = "14",

pages = "507--518",

journal = "Pain Management",

issn = "1758-1869",

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TY - JOUR

T1 - Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation

AU - Park, Juyoung

AU - Tong, Heling

AU - Kang, Yixin

AU - Miao, Hongyu

AU - Lin, Lifeng

AU - Fox, Rina S.

AU - Telkes, Ilknur

AU - Martorella, Geraldine

AU - Ahn, Hyochol

PY - 2024

Y1 - 2024

N2 - Aim: The study compared responders and nonresponders to transcranial direct current stimulation (tDCS) regarding clinical pain outcomes in knee osteoarthritis (OA) patients. Patients and Methods/Materials: Sixty participants received home-based active tDCS, and clinical pain outcomes were compared between responders and nonresponders. Results: Latent class growth analyses classified 41 participants as responders and 19 as nonresponders. Responders showed significantly greater decreases in pain intensity from baseline to post intervention than nonresponders (p <.001). Participants with higher BMI (p =.02) and weight (p =.005) were more likely to respond, while no significant sociodemographic differences were found. Conclusions: Identifying characteristics of nonresponsive tDCS subgroups can tailor treatments for each group. Clinical trial registration: www.clinicaltrials.gov identifier is NCT04016272.

AB - Aim: The study compared responders and nonresponders to transcranial direct current stimulation (tDCS) regarding clinical pain outcomes in knee osteoarthritis (OA) patients. Patients and Methods/Materials: Sixty participants received home-based active tDCS, and clinical pain outcomes were compared between responders and nonresponders. Results: Latent class growth analyses classified 41 participants as responders and 19 as nonresponders. Responders showed significantly greater decreases in pain intensity from baseline to post intervention than nonresponders (p <.001). Participants with higher BMI (p =.02) and weight (p =.005) were more likely to respond, while no significant sociodemographic differences were found. Conclusions: Identifying characteristics of nonresponsive tDCS subgroups can tailor treatments for each group. Clinical trial registration: www.clinicaltrials.gov identifier is NCT04016272.

KW - BMI

KW - Knee osteoarthritis

KW - older adults

KW - responders to tDCS

KW - transcranial direct current stimulation

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DO - 10.1080/17581869.2024.2429943

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AN - SCOPUS:85209913329

SN - 1758-1869

VL - 14

SP - 507

EP - 518

JO - Pain Management

JF - Pain Management

IS - 9

ER -

Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation

Abstract

Keywords

ASJC Scopus subject areas

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