Comparing the chemical biology of NO and HNO

Wilmarie Flores-Santana, Christopher Switzer, Lisa A. Ridnour, Debashree Basudhar, Daniele Mancardi, Sonia Donzelli, Douglas D. Thomas, Katrina M. Miranda, Jon M. Fukuto, David A. Wink

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


For the past couple of decades nitric oxide (NO) and nitroxyl (HNO) have been extensively studied due to the important role they play in many physiological and/or pharmacological processes. Many researchers have reported important signaling pathways as well as mechanisms of action of these species, showing direct and indirect effects depending on the environment. Both NO and HNO can react with, among others, metals, proteins, thiols and heme proteins via unique and distinct chemistry leading to improvement of some clinical conditions. Understanding the basic chemistry of NO and HNO and distinguishing their mechanisms of action as well as methods of detection are crucial for understanding the current and potential clinical applications. In this review, we summarize some of the most important findings regarding NO and HNO chemistry, revealing some of the possible mechanisms of their beneficial actions.

Original languageEnglish (US)
Pages (from-to)1139-1153
Number of pages15
JournalArchives of Pharmacal Research
Issue number8
StatePublished - Aug 2009


  • Cancer
  • Nitric oxide
  • Nitrosative stress

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry


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