Comparative MSH release-inhibiting activities of tocinoic acid (the ring of oxytocin), and L-Pro-L-Leu-Gly-NH2 (the side chain of oxytocin)

Sister Annette Bower; Mac E. Hadley; Victor J. Hruby

doi:10.1016/0006-291X(71)90143-4

Comparative MSH release-inhibiting activities of tocinoic acid (the ring of oxytocin), and L-Pro-L-Leu-Gly-NH₂ (the side chain of oxytocin)

Sister Annette Bower
, Mac E. Hadley
, Victor J. Hruby

Chemistry & Biochemistry - Sci

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Synthetic tocinoic acid, the ring structure of oxytocin (L-Cys-L-Tyr-L-Ile-L-Gln-L-Asn-L-Cys-OH), inhibits MSH release from the rat pituitary in vitro at less than nanogram (10^-10 g/ml) levels. A similar inhibitory activity could not be demonstrated on the amphibian (Rana pipiens) pituitary. The synthetic tripeptide side chain of oxytocin (L-Pro-L-Leu-Gly-NH₂) was devoid, in vitro, of MSH release inhibition in either the rat or the frog.

Original language	English (US)
Pages (from-to)	1185-1191
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	45
Issue number	5
DOIs	https://doi.org/10.1016/0006-291X(71)90143-4
State	Published - Dec 3 1971

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Comparative MSH release-inhibiting activities of tocinoic acid (the ring of oxytocin), and L-Pro-L-Leu-Gly-NH2 (the side chain of oxytocin)",

abstract = "Synthetic tocinoic acid, the ring structure of oxytocin (L-Cys-L-Tyr-L-Ile-L-Gln-L-Asn-L-Cys-OH), inhibits MSH release from the rat pituitary in vitro at less than nanogram (10-10 g/ml) levels. A similar inhibitory activity could not be demonstrated on the amphibian (Rana pipiens) pituitary. The synthetic tripeptide side chain of oxytocin (L-Pro-L-Leu-Gly-NH2) was devoid, in vitro, of MSH release inhibition in either the rat or the frog.",

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T1 - Comparative MSH release-inhibiting activities of tocinoic acid (the ring of oxytocin), and L-Pro-L-Leu-Gly-NH2 (the side chain of oxytocin)

AU - Bower, Sister Annette

AU - Hadley, Mac E.

AU - Hruby, Victor J.

PY - 1971/12/3

Y1 - 1971/12/3

N2 - Synthetic tocinoic acid, the ring structure of oxytocin (L-Cys-L-Tyr-L-Ile-L-Gln-L-Asn-L-Cys-OH), inhibits MSH release from the rat pituitary in vitro at less than nanogram (10-10 g/ml) levels. A similar inhibitory activity could not be demonstrated on the amphibian (Rana pipiens) pituitary. The synthetic tripeptide side chain of oxytocin (L-Pro-L-Leu-Gly-NH2) was devoid, in vitro, of MSH release inhibition in either the rat or the frog.

AB - Synthetic tocinoic acid, the ring structure of oxytocin (L-Cys-L-Tyr-L-Ile-L-Gln-L-Asn-L-Cys-OH), inhibits MSH release from the rat pituitary in vitro at less than nanogram (10-10 g/ml) levels. A similar inhibitory activity could not be demonstrated on the amphibian (Rana pipiens) pituitary. The synthetic tripeptide side chain of oxytocin (L-Pro-L-Leu-Gly-NH2) was devoid, in vitro, of MSH release inhibition in either the rat or the frog.

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Comparative MSH release-inhibiting activities of tocinoic acid (the ring of oxytocin), and L-Pro-L-Leu-Gly-NH₂ (the side chain of oxytocin)

Abstract

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