TY - JOUR
T1 - Comparative MSH release-inhibiting activities of tocinoic acid (the ring of oxytocin), and L-Pro-L-Leu-Gly-NH2 (the side chain of oxytocin)
AU - Bower, Sister Annette
AU - Hadley, Mac E.
AU - Hruby, Victor J.
PY - 1971/12/3
Y1 - 1971/12/3
N2 - Synthetic tocinoic acid, the ring structure of oxytocin (L-Cys-L-Tyr-L-Ile-L-Gln-L-Asn-L-Cys-OH), inhibits MSH release from the rat pituitary in vitro at less than nanogram (10-10 g/ml) levels. A similar inhibitory activity could not be demonstrated on the amphibian (Rana pipiens) pituitary. The synthetic tripeptide side chain of oxytocin (L-Pro-L-Leu-Gly-NH2) was devoid, in vitro, of MSH release inhibition in either the rat or the frog.
AB - Synthetic tocinoic acid, the ring structure of oxytocin (L-Cys-L-Tyr-L-Ile-L-Gln-L-Asn-L-Cys-OH), inhibits MSH release from the rat pituitary in vitro at less than nanogram (10-10 g/ml) levels. A similar inhibitory activity could not be demonstrated on the amphibian (Rana pipiens) pituitary. The synthetic tripeptide side chain of oxytocin (L-Pro-L-Leu-Gly-NH2) was devoid, in vitro, of MSH release inhibition in either the rat or the frog.
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U2 - 10.1016/0006-291X(71)90143-4
DO - 10.1016/0006-291X(71)90143-4
M3 - Article
C2 - 5135504
AN - SCOPUS:0015209666
SN - 0006-291X
VL - 45
SP - 1185
EP - 1191
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 5
ER -