Comparative efficacy of nonsteroidal anti-inflammatory drugs and anti-thromboxane agents in a rabbit adhesion-prevention model

Edmund K. Legrand, Kathleen E. Rodgers, Wefki Girgis, Joseph D. Campeau, Gere S. Dizerega

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A variety of nonsteroidal anti-inflammatory drugs (NSAIDs) has been found to inhibit postsurgical peritoneal adhesion formation in a number of animal models. A rabbit uterine horn adhesion model was used to directly compare several commonly used NSAIDs of different chemical classes in a single animal study to evaluate their ability to prevent adhesion formation. The effect of thromboxane inhibitors on adhesion prevention was also evaluated. Each of the MAIDS tested (tolmetin, ibuprofen, aspirin, and indomethacin) showed significant and comparable efficacy. In this same study, imidazole, a thromboxane synthetase inhibitor, also showed significant efficacy. In a second study, ridogrel, an inhibitor of thromboxane synthetase as well as a thromboxane A2 receptor blocker, also showed significant efficacy in reducing peritoneal adhesion severity. These results further support the view that NSAIDs act to prevent adhesions through a common mechanism. In addition, thromboxane A, inhibitors were also shown to be efficacious in adhesion prevention, suggesting that platelets may pray a substantial role in adhesion format on.

Original languageEnglish (US)
Pages (from-to)187-194
Number of pages8
JournalJournal of Investigative Surgery
Volume8
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Adhesion prevention
  • Nonsteroidal anti-inflammatory drug
  • Peritoneum
  • Rabbit
  • Thromboxane

ASJC Scopus subject areas

  • Surgery

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