TY - JOUR
T1 - Comparative effects of antioxidants on the toxicity of mixed pyrrolizidine alkaloids from senecio jacobaea in mice
AU - Miranda, Cristobal L.
AU - Henderson, Marilyn C.
AU - Buhler, Donald R.
AU - Schmitz, John A.
N1 - Funding Information:
This work was supported by National Institutes of Health grants CA-22524 and ES-00210. This manuscript was issued as Oregon Agricultural Experiment Station Technical Paper No. 5894. Requests for reprints should be sent to Donald R. Buhler, Professor, Department of Agricultural Chemistry, Oregon State University, Corvallis, Oregon 97331.
PY - 1982
Y1 - 1982
N2 - The comparative effects of the antioxidants, butylated hydroxyanisole (BHA), ethoxy- quin, and cysteine on pyrrolizidine-alkaloid-induced (PA-induced) lethality and acute hepatotoxicity were assessed in female mice. Diets containing 0.75% BHA, 0.25% ethoxyquin, or 1% cysteine were fed to mice for 10 d before the ip administration of mixed PAs from Senecio jacobaea (tansy ragwort), 280 mg/kg. Without the dietary antioxidants, the PAs produced 100% mortality in 24 h. The BHA and ethoxyquin diets were completely and partially protective, respectively, against the PA-induced lethality. The deaths were associated with severe hemorrhagic lesions in liver with or without hepatocytic necrosis. Both BHA and ethoxyquin significantly reduced the incidence of the hemorrhagic lesions but not the necrotic lesions in liver. Cysteine had no significant effect on either mortality or the liver lesions induced by the mixed PAs. These results suggest that dietary antioxidants have differential protective effects against lethality and acute hepatotoxicity induced by mixed PAs from tansy ragwort.
AB - The comparative effects of the antioxidants, butylated hydroxyanisole (BHA), ethoxy- quin, and cysteine on pyrrolizidine-alkaloid-induced (PA-induced) lethality and acute hepatotoxicity were assessed in female mice. Diets containing 0.75% BHA, 0.25% ethoxyquin, or 1% cysteine were fed to mice for 10 d before the ip administration of mixed PAs from Senecio jacobaea (tansy ragwort), 280 mg/kg. Without the dietary antioxidants, the PAs produced 100% mortality in 24 h. The BHA and ethoxyquin diets were completely and partially protective, respectively, against the PA-induced lethality. The deaths were associated with severe hemorrhagic lesions in liver with or without hepatocytic necrosis. Both BHA and ethoxyquin significantly reduced the incidence of the hemorrhagic lesions but not the necrotic lesions in liver. Cysteine had no significant effect on either mortality or the liver lesions induced by the mixed PAs. These results suggest that dietary antioxidants have differential protective effects against lethality and acute hepatotoxicity induced by mixed PAs from tansy ragwort.
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U2 - 10.1080/15287398209530215
DO - 10.1080/15287398209530215
M3 - Article
C2 - 7120519
AN - SCOPUS:0019953935
SN - 0098-4108
VL - 9
SP - 933
EP - 939
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
IS - 5-6
ER -