Compact CT/SPECT small-animal imaging system

George A. Kastis; Lars R. Furenlid; Donald W. Wilson; Todd E. Peterson; H. Bradford Barber; Harrison H. Barrett

doi:10.1109/TNS.2004.823337

Compact CT/SPECT small-animal imaging system

George A. Kastis, Lars R. Furenlid, Donald W. Wilson, Todd E. Peterson, H. Bradford Barber, Harrison H. Barrett

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64 × 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.

Original language	English (US)
Pages (from-to)	63-67
Number of pages	5
Journal	IEEE Transactions on Nuclear Science
Volume	51
Issue number	1 I
DOIs	https://doi.org/10.1109/TNS.2004.823337
State	Published - Feb 2004

Keywords

Biomedical imaging
Cadmium zinc telluride (CdZnTe)
Multimodality imaging
Single-photon emission computed tomography
Small-animal imaging

ASJC Scopus subject areas

Nuclear and High Energy Physics
Nuclear Energy and Engineering
Electrical and Electronic Engineering

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10.1109/TNS.2004.823337

Cite this

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title = "Compact CT/SPECT small-animal imaging system",

abstract = "We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64 × 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.",

keywords = "Biomedical imaging, Cadmium zinc telluride (CdZnTe), Multimodality imaging, Single-photon emission computed tomography, Small-animal imaging",

author = "Kastis, {George A.} and Furenlid, {Lars R.} and Wilson, {Donald W.} and Peterson, {Todd E.} and Barber, {H. Bradford} and Barrett, {Harrison H.}",

note = "Funding Information: Manuscript received December 19, 2002; revised April 21, 2003. This work was supported by the National Institutes of Health under Grants R24 CA83148 (Southwest Animal Imaging Resource) and P41 RR14304 (Center for Gamma-Ray Imaging). The work of T. E. Peterson, Ph.D., was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund.",

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language = "English (US)",

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AU - Furenlid, Lars R.

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AU - Barber, H. Bradford

AU - Barrett, Harrison H.

N1 - Funding Information: Manuscript received December 19, 2002; revised April 21, 2003. This work was supported by the National Institutes of Health under Grants R24 CA83148 (Southwest Animal Imaging Resource) and P41 RR14304 (Center for Gamma-Ray Imaging). The work of T. E. Peterson, Ph.D., was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund.

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AB - We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64 × 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.

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Compact CT/SPECT small-animal imaging system

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Keywords

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