Abstract
We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The x-ray system comprises a commercially available micro-focus x-ray tube and a CCD-based x-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the x-ray tube/CCD combination. It consists of a 64 × 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and x-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed.
| Original language | English (US) |
|---|---|
| Pages | 797-801 |
| Number of pages | 5 |
| State | Published - 2002 |
| Event | 2002 IEEE Nuclear Science Symposium Conference Record - Norfolk, VA, United States Duration: Nov 10 2002 → Nov 16 2002 |
Other
| Other | 2002 IEEE Nuclear Science Symposium Conference Record |
|---|---|
| Country/Territory | United States |
| City | Norfolk, VA |
| Period | 11/10/02 → 11/16/02 |
Keywords
- Biomedical imaging
- Cadmium Zinc Telluride (CdZnTe)
- Multi-modality imaging
- Single-photon emission computed tomography
- Small-animal imaging
ASJC Scopus subject areas
- Radiation
- Nuclear and High Energy Physics
- Radiology Nuclear Medicine and imaging