Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling"

Barbara Burtness; Shanthi Marur; Julie E. Bauman; Erica A. Golemis; Ranee Mehra; Steven J. Cohen

doi:10.1126/scisignal.2003734

Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling"

Barbara Burtness, Shanthi Marur, Julie E. Bauman, Erica A. Golemis, Ranee Mehra, Steven J. Cohen

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) play important roles in tumor growth, which has stimulated efforts toward the design of targeted cancer therapeutics that inhibit their function. A growing body of literature indicates that EGFR and mTOR are also essential to support a functional innate immune response. Hence, although combination therapies that block both EGFR and mTOR may have improved activity against tumors, they may also place patients at risk of fulminant infections. We discuss data supporting this hypothesis.

Original language	English (US)
Article number	lc5
Journal	Science signaling
Volume	5
Issue number	254
DOIs	https://doi.org/10.1126/scisignal.2003734
State	Published - Dec 11 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1126/scisignal.2003734

Cite this

@article{f872871c63004bd3af8d054a01ee2dcb,

title = "Comment on {"}epidermal growth factor receptor is essential for toll-like receptor 3 signaling{"}",

abstract = "Epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) play important roles in tumor growth, which has stimulated efforts toward the design of targeted cancer therapeutics that inhibit their function. A growing body of literature indicates that EGFR and mTOR are also essential to support a functional innate immune response. Hence, although combination therapies that block both EGFR and mTOR may have improved activity against tumors, they may also place patients at risk of fulminant infections. We discuss data supporting this hypothesis.",

author = "Barbara Burtness and Shanthi Marur and Bauman, {Julie E.} and Golemis, {Erica A.} and Ranee Mehra and Cohen, {Steven J.}",

year = "2012",

month = dec,

day = "11",

doi = "10.1126/scisignal.2003734",

language = "English (US)",

volume = "5",

journal = "Science signaling",

issn = "1945-0877",

publisher = "American Association for the Advancement of Science",

number = "254",

}

TY - JOUR

T1 - Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling"

AU - Burtness, Barbara

AU - Marur, Shanthi

AU - Bauman, Julie E.

AU - Golemis, Erica A.

AU - Mehra, Ranee

AU - Cohen, Steven J.

PY - 2012/12/11

Y1 - 2012/12/11

N2 - Epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) play important roles in tumor growth, which has stimulated efforts toward the design of targeted cancer therapeutics that inhibit their function. A growing body of literature indicates that EGFR and mTOR are also essential to support a functional innate immune response. Hence, although combination therapies that block both EGFR and mTOR may have improved activity against tumors, they may also place patients at risk of fulminant infections. We discuss data supporting this hypothesis.

AB - Epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) play important roles in tumor growth, which has stimulated efforts toward the design of targeted cancer therapeutics that inhibit their function. A growing body of literature indicates that EGFR and mTOR are also essential to support a functional innate immune response. Hence, although combination therapies that block both EGFR and mTOR may have improved activity against tumors, they may also place patients at risk of fulminant infections. We discuss data supporting this hypothesis.

UR - http://www.scopus.com/inward/record.url?scp=84871119463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871119463&partnerID=8YFLogxK

U2 - 10.1126/scisignal.2003734

DO - 10.1126/scisignal.2003734

M3 - Article

C2 - 23233526

AN - SCOPUS:84871119463

SN - 1945-0877

VL - 5

JO - Science signaling

JF - Science signaling

IS - 254

M1 - lc5

ER -

Comment on "epidermal growth factor receptor is essential for toll-like receptor 3 signaling"

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this