Come FLY with us: Toward understanding fragile X syndrome

D. C. Zarnescu, G. Shan, S. T. Warren, P. Jin

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


The past few years have seen an increased number of articles using Drosophila as a model system to study fragile X syndrome. Phenotypic analyses have demonstrated an array of neuronal and behavioral defects similar to the phenotypes reported in mouse models as well as human patients. The availability of both cellular and molecular tools along with the power of genetics makes the tiny fruit fly a premiere model in elucidating the molecular basis of fragile X syndrome. Here, we summarize the advances made in recent years in the characterization of fragile X Drosophila models and the identification of new molecular partners in neural development.

Original languageEnglish (US)
Pages (from-to)385-392
Number of pages8
JournalGenes, Brain and Behavior
Issue number6
StatePublished - Aug 2005


  • Drosophila
  • FMRP
  • Fragile X syndrome
  • dFmr1

ASJC Scopus subject areas

  • Genetics
  • Neurology
  • Behavioral Neuroscience


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