Combined endoscopic optical coherence tomography and laser induced fluorescence

Jennifer K. Barton, Alexandre R. Tumlinson, Urs Utzinger

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Optical coherence tomography (OCT) and laser-induced fluorescence (LIF) are promising modalities for tissue characterization in human patients and animal models. OCT detects coherently backscattered light, whereas LIF detects fluorescence emission of endogenous biochemicals, such as reduced nicotinamide adenine dinucleotide (NADH), flavin adenine dinucleotide (FAD), collagen, and fluorescent proteins, or exogenous substances such as cyanine dyes. Given the complementary mechanisms of contrast for OCT and LIF, the combination of the two modalities could potentially provide more sensitive and specific detection of disease than either modality alone. Sample probes for both OCT and LIF can be implemented using small diameter optical fibers, suggesting a particular synergy for endoscopic applications. In this chapter, the mechanisms of contrast and diagnostic capability for both OCT and LIF are briefly examined. Evidence of complementary capability is described. Example published combined OCT–LIF systems are reviewed, one successful commercial instrument is discussed, and example applications are provided.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography
Subtitle of host publicationTechnology and Applications, Second Edition
PublisherSpringer International Publishing
Number of pages41
ISBN (Electronic)9783319064192
ISBN (Print)9783319064185
StatePublished - Jan 1 2015


  • Dual-modality
  • Endoscopy
  • Fluorescence imaging
  • Fluorescence spectroscopy
  • Optical coherence tomography

ASJC Scopus subject areas

  • General Physics and Astronomy
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering


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