Colon cancer: The role of sphingolipid metabolic enzymes

Hideki Furuya, Songhwa Choi, Lina M. Obeid, Toshihiko Kawamori, Ashley J. Snider

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Colorectal cancer is one of the most common tumors worldwide, with sustained incidence in developed countries and increasing incidence in developing countries. Although recent studies provide knowledge of the molecular signaling pathways that are implicated in colon carcinogenesis, treatments and outcomes still need further improvement. Bioactive sphingolipids, such as ceramide, sphingosine, and sphingosine-1-phosphate (S1P), are signaling molecules that regulate cellular events including cell proliferation, apoptosis, senescence, angiogenesis, and transformation in response to diverse stimuli. Ceramide and sphingosine mediate numerous cell-stress responses, including induction of apoptosis and cell senescence. In contrast, S1P plays pivotal roles in cell survival, migration, and inflammation. These sphingolipids with opposing roles can be quickly metabolized and catabolized within cells, suggesting that the balance between these potent bioactive lipids may dictate cell fate. In this chapter, we review the roles of these bioactive sphingolipids and their metabolic enzymes in colitis, colitis associated cancer, and colorectal cancer

Original languageEnglish (US)
Title of host publicationBioactive Sphingolipids in Cancer Biology and Therapy
PublisherSpringer International Publishing
Pages141-159
Number of pages19
ISBN (Electronic)9783319207506
ISBN (Print)9783319207490
DOIs
StatePublished - Aug 28 2015
Externally publishedYes

Keywords

  • Ceramide
  • Colon cancer
  • Cyclooxygenase 2
  • Inflammatory bowel disease
  • Signal transducer and activator of transcription 3
  • Sphingosine kinase
  • Sphingosine- 1- phosphate

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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