TY - JOUR
T1 - Cohesive cancer invasion of the biophysical barrier of smooth muscle
AU - Harryman, William L.
AU - Marr, Kendra D.
AU - Hernandez-Cortes, Daniel
AU - Nagle, Raymond B.
AU - Garcia, Joe G.N.
AU - Cress, Anne E.
N1 - Funding Information:
The work was supported by the National Cancer Institute of the National Institutes of Health under award numbers P30 CA023074 and F30 CA247106.
Funding Information:
We acknowledge staff support of the Tissue Acquisition and Cellular/Molecular Analysis Resource at the University of Arizona Cancer Center and the funding sources that made the work possible, including NIH-NCI T32CA009213 (to A.E. Cress), NIH-NHLBI P01 HL126609 (to J.G.N. Garcia), Project 3 (to A.E. Cress), NCI-P30 CA 23074, and F30 CA247106 to K.D. Marr.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
PY - 2021/3
Y1 - 2021/3
N2 - Smooth muscle is found around organs in the digestive, respiratory, and reproductive tracts. Cancers arising in the bladder, prostate, stomach, colon, and other sites progress from low-risk disease to high-risk, lethal metastatic disease characterized by tumor invasion into, within, and through the biophysical barrier of smooth muscle. We consider here the unique biophysical properties of smooth muscle and how cohesive clusters of tumor use mechanosensing cell–cell and cell–ECM (extracellular matrix) adhesion receptors to move through a structured muscle and withstand the biophysical forces to reach distant sites. Understanding integrated mechanosensing features within tumor cluster and smooth muscle and potential triggers within adjacent adipose tissue, such as the unique damage-associated molecular pattern protein (DAMP), eNAMPT (extracellular nicotinamide phosphoribosyltransferase), or visfatin, offers an opportunity to prevent the first steps of invasion and metastasis through the structured muscle.
AB - Smooth muscle is found around organs in the digestive, respiratory, and reproductive tracts. Cancers arising in the bladder, prostate, stomach, colon, and other sites progress from low-risk disease to high-risk, lethal metastatic disease characterized by tumor invasion into, within, and through the biophysical barrier of smooth muscle. We consider here the unique biophysical properties of smooth muscle and how cohesive clusters of tumor use mechanosensing cell–cell and cell–ECM (extracellular matrix) adhesion receptors to move through a structured muscle and withstand the biophysical forces to reach distant sites. Understanding integrated mechanosensing features within tumor cluster and smooth muscle and potential triggers within adjacent adipose tissue, such as the unique damage-associated molecular pattern protein (DAMP), eNAMPT (extracellular nicotinamide phosphoribosyltransferase), or visfatin, offers an opportunity to prevent the first steps of invasion and metastasis through the structured muscle.
KW - Bladder
KW - Cohesive clusters
KW - Mechanosensing
KW - Prostate
KW - Smooth muscle
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U2 - 10.1007/s10555-020-09950-2
DO - 10.1007/s10555-020-09950-2
M3 - Review article
C2 - 33398621
AN - SCOPUS:85098858400
SN - 0167-7659
VL - 40
SP - 205
EP - 219
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
IS - 1
ER -