TY - JOUR
T1 - Cognitively Based Compassion Training for HIV Immune Nonresponders - An Attention-Placebo Randomized Controlled Trial
AU - Titanji, Boghuma K.
AU - Tejani, Mehul
AU - Farber, Eugene W.
AU - Mehta, C. Christina
AU - Pace, Thaddeus W.
AU - Meagley, Kathryn
AU - Gavegnano, Christina
AU - Harrison, Timothy
AU - Kokubun, Caroline W.
AU - Negi, Satya Dev
AU - Schinazi, Raymond F.
AU - Marconi, Vincent C.
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Objective: Chronic inflammation is associated with increased morbidity and mortality for people with HIV (PWH). Psychological stress is an important contributor to this chronic inflammation. We hypothesized that a cognitively based compassion training (CBCT) approach could reduce inflammation and psychological stress in immune nonresponder PWH. Design: An attention-placebo randomized controlled trial design to evaluate the acceptability of CBCT among PWH and its effects on key aspects of stress and immune function compared with an active-attention control group (NCT02395289). Methods: This study was conducted at an HIV clinic in Atlanta, Georgia. Eligible individuals determined by (1) adherence to antiretroviral therapy for at least a year, (2) virologic suppression; and (3) stable CD4+T-cell counts <350 cells/L were randomized in a 2:1 ratio to either CBCT or control in 2 study periods: April-May, 2016, and September-December, 2016. Psychological measures and inflammatory biomarkers associated with HIV disease progression (IL-1β, TNF-α, sCD14, IL-6, and IL-10) were obtained for all study participants at baseline and at the time of study completion. Results: We found a significant association between CBCT practice time engagement and fold reduction in IL-6 and TNF-α levels. There was no association between CBCT practice time and other biomarkers markers assessed (IL-1β, sCD14, and IL-10). These changes were coincident with significant increases in self-reported psychological well-being and HIV disease acceptance and in benefits for CBCT participants. We also observed fewer instances of virologic failure for those in the CBCT arm compared with controls. Conclusions: CBCT is a novel and feasible nonmedication-based intervention that could reduce inflammation and psychological stress in PWH.
AB - Objective: Chronic inflammation is associated with increased morbidity and mortality for people with HIV (PWH). Psychological stress is an important contributor to this chronic inflammation. We hypothesized that a cognitively based compassion training (CBCT) approach could reduce inflammation and psychological stress in immune nonresponder PWH. Design: An attention-placebo randomized controlled trial design to evaluate the acceptability of CBCT among PWH and its effects on key aspects of stress and immune function compared with an active-attention control group (NCT02395289). Methods: This study was conducted at an HIV clinic in Atlanta, Georgia. Eligible individuals determined by (1) adherence to antiretroviral therapy for at least a year, (2) virologic suppression; and (3) stable CD4+T-cell counts <350 cells/L were randomized in a 2:1 ratio to either CBCT or control in 2 study periods: April-May, 2016, and September-December, 2016. Psychological measures and inflammatory biomarkers associated with HIV disease progression (IL-1β, TNF-α, sCD14, IL-6, and IL-10) were obtained for all study participants at baseline and at the time of study completion. Results: We found a significant association between CBCT practice time engagement and fold reduction in IL-6 and TNF-α levels. There was no association between CBCT practice time and other biomarkers markers assessed (IL-1β, sCD14, and IL-10). These changes were coincident with significant increases in self-reported psychological well-being and HIV disease acceptance and in benefits for CBCT participants. We also observed fewer instances of virologic failure for those in the CBCT arm compared with controls. Conclusions: CBCT is a novel and feasible nonmedication-based intervention that could reduce inflammation and psychological stress in PWH.
KW - CBCT
KW - HIV
KW - immune nonresponders
KW - inflammation
KW - mindfulness
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UR - http://www.scopus.com/inward/citedby.url?scp=85124606749&partnerID=8YFLogxK
U2 - 10.1097/QAI.0000000000002874
DO - 10.1097/QAI.0000000000002874
M3 - Article
C2 - 34879006
AN - SCOPUS:85124606749
SN - 1525-4135
VL - 89
SP - 340
EP - 348
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 3
ER -