TY - JOUR
T1 - Cognitive modules utilized for narrative comprehension in children
T2 - A functional magnetic resonance imaging study
AU - Schmithorst, Vincent J.
AU - Holland, Scott K.
AU - Plante, Elena
N1 - Funding Information:
This work was supported by a grant from the U.S. National Institute of Child Health and Human Development, #R01-HD38578. The authors acknowledge the assistance of Dr. Anna Byars, PhD, in the administration of the Wechsler Full-Scale IQ tests; and of Drs. Richard Strawsburg, MD, and Mark Schapiro, MD, for performing the neurological examinations.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - The ability to comprehend narratives constitutes an important component of human development and experience. The neural correlates of auditory narrative comprehension in children were investigated in a large-scale functional magnetic resonance imaging (fMRI) study involving 313 subjects ages 5-18. Using group independent component analysis (ICA), bilateral task-related components were found comprising the primary auditory cortex, the mid-superior temporal gyrus, the hippocampus, the angular gyrus, and medial aspect of the parietal lobule (precuneus/posterior cingulate). In addition, a right-lateralized component was found involving the most posterior aspect of the superior temporal gyrus, and a left-lateralized component was found comprising the inferior frontal gyrus (including Broca's area), the inferior parietal lobule, and the medial temporal gyrus. Using a novel data-driven analysis technique, increased task-related activity related to age was found in the components comprising the mid-superior temporal gyrus (Wernicke's area) and the posterior aspect of the superior temporal gyrus, while decreased activity related to age was found in the component comprising the angular gyrus. The results are discussed in light of recent hypotheses involving the functional segregation of Wernicke's area and the specific role of the mid-superior temporal gyrus in speech comprehension.
AB - The ability to comprehend narratives constitutes an important component of human development and experience. The neural correlates of auditory narrative comprehension in children were investigated in a large-scale functional magnetic resonance imaging (fMRI) study involving 313 subjects ages 5-18. Using group independent component analysis (ICA), bilateral task-related components were found comprising the primary auditory cortex, the mid-superior temporal gyrus, the hippocampus, the angular gyrus, and medial aspect of the parietal lobule (precuneus/posterior cingulate). In addition, a right-lateralized component was found involving the most posterior aspect of the superior temporal gyrus, and a left-lateralized component was found comprising the inferior frontal gyrus (including Broca's area), the inferior parietal lobule, and the medial temporal gyrus. Using a novel data-driven analysis technique, increased task-related activity related to age was found in the components comprising the mid-superior temporal gyrus (Wernicke's area) and the posterior aspect of the superior temporal gyrus, while decreased activity related to age was found in the component comprising the angular gyrus. The results are discussed in light of recent hypotheses involving the functional segregation of Wernicke's area and the specific role of the mid-superior temporal gyrus in speech comprehension.
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U2 - 10.1016/j.neuroimage.2005.07.020
DO - 10.1016/j.neuroimage.2005.07.020
M3 - Article
C2 - 16109491
AN - SCOPUS:29244481134
SN - 1053-8119
VL - 29
SP - 254
EP - 266
JO - NeuroImage
JF - NeuroImage
IS - 1
ER -