Cognitive Impairment and the Dementias

Ranjan Duara, Miriam Jocelyn Rodriguez, David A. Loewenstein, Martin R. Farlow, Clive Ballard, Helena C. Chui, Freddi Segal-Gidan, David Perry, Howard Rosen, Maya L. Henry, Stephen M. Wilson, Steven Z. Rapcsak, Michael D. Geschwind, Katherine Wong, Norman R. Relkin

Research output: Chapter in Book/Report/Conference proceedingChapter


Summary: The term mild cognitive impairment (MCI) was introduced as a stage in the Global Deterioration Scale to describe the progression from normal aging to dementia. Alzheimer's disease (AD) is the most common form of dementia in the United States. The potential clinical and demographic risk factors for developing AD at an earlier age of onset identified over the last three decades include depression, female gender, low levels of education, smaller head circumference, and family history of Down's syndrome. Dementia with Lewy bodies (DLB) is a synucleinopathy characterized by a progressive dementia syndrome that is usually associated with parkinsonism and typically dominated by attentional, visuospatial, and executive dysfunction and relatively preserved memory. Vascular cognitive impairment, frontotemporal dementia, primary progressive aphasia, prion diseases, and normal pressure hydrocephalus are also discussed in the chapter.

Original languageEnglish (US)
Title of host publicationGeriatric Neurology
Number of pages106
ISBN (Electronic)9781118730676
ISBN (Print)9781118730683
StatePublished - Mar 28 2014


  • Alzheimer's disease (AD)
  • Cognitive impairment
  • Dementia with Lewy bodies (DLB)
  • Dementias
  • Mild cognitive impairment (MCI)
  • Normal pressure hydrocephalus
  • Primary progressive aphasia
  • Prion diseases
  • Vascular cognitive impairment

ASJC Scopus subject areas

  • General Medicine


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