TY - JOUR
T1 - Cognitive Assessment in Alzheimer's Disease
T2 - Cross-Sectional and Longitudinal Perspectives
AU - Kaszniak, Alfred W.
AU - Wilson, Robert S.
AU - Fox, Jacob H.
AU - Stebbins, Glenn T.
PY - 1986/11
Y1 - 1986/11
N2 - This paper describes select results of a longitudinal study of 62 mild to moderate Alzheimer's disease (AD) patients, in comparison to 60 age-matched healthy controls. Initial neurologic, radiologic, psychiatric, laboratory and cognitive examinations, required two full days, followed by one-day examinations at annual intervals. Of the total original sample, 31 AD patients and 39 controls could actually be followed for three annual examinations. Cognitive examination data confirmed cross-sectional (group discriminative) validity of memory and language measures, and showed the expected longitudinal deterioration in the AD sample, with controls maintaining consistent performance over the three years. However, those measures showing largest group differences at initial examination were not the best for tracking patient deterioration over time. Implications of these results for the selection of cognitive assessment measures are discussed.
AB - This paper describes select results of a longitudinal study of 62 mild to moderate Alzheimer's disease (AD) patients, in comparison to 60 age-matched healthy controls. Initial neurologic, radiologic, psychiatric, laboratory and cognitive examinations, required two full days, followed by one-day examinations at annual intervals. Of the total original sample, 31 AD patients and 39 controls could actually be followed for three annual examinations. Cognitive examination data confirmed cross-sectional (group discriminative) validity of memory and language measures, and showed the expected longitudinal deterioration in the AD sample, with controls maintaining consistent performance over the three years. However, those measures showing largest group differences at initial examination were not the best for tracking patient deterioration over time. Implications of these results for the selection of cognitive assessment measures are discussed.
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U2 - 10.1017/S0317167100037033
DO - 10.1017/S0317167100037033
M3 - Article
C2 - 3491663
AN - SCOPUS:0022970650
SN - 0317-1671
VL - 13
SP - 420
EP - 423
JO - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
JF - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
IS - S4
ER -