Codon usage in genes coding for proteins with different folding types

195 genes codings for proteins in four different folding types were analyzed in terms of variance analysis, in which there are 50 genes codings for all α proteins, 66 entries for all β proteins, 37 entries for α + β proteins and 42 entries for α/β proteins. It was observed that codon usage in different gene classes codings for different folding proteins is significantly different. Similar to amino acid propensities in different protein classes, folding type - specific proteins have specific codon usage patterns. With the help of codon usage pattern, the prediction of protein folding type and further prediction of protein secondary structure can be improved.